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Neuraminidase

All articles tagged with #neuraminidase

health1 hour ago•1 min saved

GSK gears up for phase 3 with mRNA flu vaccine after promising phase 2 data

GSK reports its mRNA influenza vaccine candidates elicited higher immune responses than standard and high-dose vaccines in a 971-participant phase 2 trial, with acceptable safety. The company plans a phase 3 study this month for the optimized FLUm3HA.b-3NA candidate (targeting HA and NA), aiming to boost its faltering flu business amid a market historically characterized by variable vaccine effectiveness. Moderna’s recent FDA approval of an mRNA flu vaccine underscores the growing role of mRNA approaches in flu protection.

via Fierce Biotech|

#gsk #health #influenza-vaccine

health6 months ago•17 min saved

Chasing a universal flu vaccine: hitting the virus where it stays the same

Scientists are pursuing a universal flu vaccine that would protect against many influenza strains by targeting conserved parts of the virus; multiple candidates are in trials using approaches such as focusing the immune response on the virus's stable cone of haemagglutinin, exposing fixed regions by presenting thousands of HA variations, blocking neuraminidase, stimulating T cells, or nasal delivery, and some work also explores AI-assisted strain selection. While a true universal vaccine may take years, interim gains include more durable protection and higher-dose shots for older adults, with experts optimistic about improvements within about five to ten years.

via BBC|

#artificial-intelligence #haemagglutinin #health

health2 years ago•3 min saved

"Novel Antibodies Combat Influenza Virus Protein's Hidden Side"

Researchers at the National Institutes of Health have discovered antibodies that target a hidden region of the influenza virus neuraminidase (NA) protein, known as the "dark side," which is common among many influenza viruses, including H3N2 subtype viruses. These antibodies could be a new target for countermeasures and have the potential to improve influenza vaccines and other treatments. The study suggests that antibodies targeting the NA dark side could be effective against influenza viruses with drug-resistant mutations and may be included in the next generation of broadly protective vaccines against influenza.

via National Institutes of Health (NIH) (.gov)|

#antibodies #health #influenza