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Antibodies

All articles tagged with #antibodies

Tampered Images Question the Reliability of Commercial Antibodies
science1 day ago

Tampered Images Question the Reliability of Commercial Antibodies

A postdoctoral researcher group led by Reese Richardson and Sholto David found widespread image manipulation in marketing images for about 17,500 commercially sold antibodies from 16 companies, with roughly 7% of examined images showing edits like brightness/contrast changes, background noise removal, or copied/pasted data. These manipulations can mislead researchers about an antibody’s effectiveness, risking wasted time and money on troubleshooting experiments that may never yield reliable results.

via Ars Technica|
#antibodies#biotechnology#image-manipulation
Infinimmune lands $75M Series A to push eczema antibodies forward
biotech15 days ago

Infinimmune lands $75M Series A to push eczema antibodies forward

Biotech startup Infinimmune raises $75 million in a Series A led by Regeneron Ventures (with Playground Global) to advance its human B cell–based antibody platform for eczema, including lead antibodies IFX-201 and IFX-101 moving to Phase 1 next year. Regeneron’s investment aims to complement Dupixent, Merck remains an investor, and the company envisions additional large‑pharma partnerships as it advances its pipeline.

via Fierce Biotech|
#antibodies#biotech#eczema
Patents’ favorite papers: the science most cited in filings
technology21 days ago

Patents’ favorite papers: the science most cited in filings

Nature analyzes which scholarly papers appear most often on patent front pages and in their text, revealing that life-science research—especially antibody science and bioinformatics tools like BLAST—dominates patent citations. Notable examples include the 1975 Köhler–Milstein monoclonal antibody paper (highly cited in patents), a 1994 Colman antibody paper with thousands of patent mentions despite few journal citations, and the 1990 BLAST software paper as the most-cited front-page patent reference. The study, drawing on The Lens and Reliance on Science datasets, shows patent references are driven by legal needs to map state of the art and that many top-cited papers are publicly funded; differences between front-page and in-text citations also reveal how methods and plant biology papers accrue patent mentions.

via nature.com|
#antibodies#biotechnology#blast
Georgia Woman Is First in State to Survive Heart Failure with HALT Procedure
health1 month ago

Georgia Woman Is First in State to Survive Heart Failure with HALT Procedure

Monica McFarlan, diagnosed with heart failure at 37, endured 15 years of LVADs and life-threatening complications and was deemed ineligible for a traditional heart transplant due to high antibody levels. She became the first in Georgia to receive the groundbreaking Heart-After-Liver Transplant (HALT), a 16-hour procedure that first replaces the liver to reset the immune system before a heart transplant, bypassing the antibody barrier and giving her a new chance at life.

via AOL.com|
#antibodies#halt#health
Georgia Woman Becomes State’s First HALT Transplant Recipient, Saving Her Failing Heart
health1 month ago

Georgia Woman Becomes State’s First HALT Transplant Recipient, Saving Her Failing Heart

Monica McFarlan, diagnosed with heart failure at 37, endured years of surgeries and LVADs and was deemed ineligible for a traditional heart transplant due to high antibodies. In a groundbreaking 16-hour Heart-After-Liver Transplant (HALT), doctors first transplant a liver to reset her immune system, then perform the heart transplant, making her the first patient in Georgia to receive this treatment and giving her a life-saving second chance while she remains on lifelong immunosuppression.

via Yahoo News Canada|
#antibodies#georgia#halt
Tick-Borne Antibody Signals Higher Red Meat Allergy Risk Than Expected
health1 month ago

Tick-Borne Antibody Signals Higher Red Meat Allergy Risk Than Expected

A CDC analysis of 3,000 adults across 10 states found about 24% in five states with high lone star tick activity have antibodies to alpha-gal, indicating prior tick bites and potential risk for alpha-gal syndrome (a red meat allergy). Antibodies show exposure, not disease, so not everyone will develop symptoms. The true prevalence is uncertain, and cases are not nationally notifiable; ticks and affected areas may expand as deer move and winters warm. Symptoms typically appear hours after eating red meat, and the condition is lifelong once developed.

via NBC News|
#alpha-gal-syndrome#antibodies#health
Widespread image manipulation flagged in Thermo Fisher antibody catalog
science2 months ago

Widespread image manipulation flagged in Thermo Fisher antibody catalog

Researchers documented 127 problematic images in Thermo Fisher's antibody catalogue, finding more than 100 manipulated images—ranging from duplicated western blot bands to painted backgrounds and identical blot backdrops. The findings contribute to ongoing concerns about the reliability of commercial antibodies; Thermo Fisher says it is conducting an internal review and will inform users when images have been optimized for presentation.

via Nature|
#antibodies#image-manipulation#science
Lab-made antibodies offer potential post-exposure measles therapy
science3 months ago

Lab-made antibodies offer potential post-exposure measles therapy

Scientists isolated four potent monoclonal antibodies from a vaccinated donor’s blood that block measles by targeting the virus’s H and F proteins. In rodent tests, these antibodies reduced lung virus after exposure, suggesting potential post-exposure or preventive use, though they are not a substitute for vaccination and delivery challenges remain. Further testing is needed before any human therapy.

via The Washington Post|
#antibodies#measles#monoclonal-antibodies
Antibody Breakthrough Blocks Epstein-Barr Virus in Mice, Could Aid Transplant Patients
science3 months ago

Antibody Breakthrough Blocks Epstein-Barr Virus in Mice, Could Aid Transplant Patients

Epstein-Barr virus (EBV) infects about 95% of adults and can persist for life, with links to cancers and other complications. A team from Fred Hutchinson Cancer Center and the University of Washington developed human-like antibodies targeting EBV surface proteins gp350 and gp42, isolating 10 candidates. In mice with humanized immune systems, one antibody provided protection against EBV, demonstrating a new approach to prevent infection and reactivation. The work could help immunosuppressed transplant patients by reducing EBV-related complications (PTLD), but human safety testing and clinical trials are still needed. Published in Cell Reports Medicine (2026).

via ScienceAlert|
#antibodies#epstein-barr-virus#gp350
Why the Rare Vaccine-Linked Clots Happen, Explained
science5 months ago

Why the Rare Vaccine-Linked Clots Happen, Explained

An international study of 100 VITT patients shows the condition starts with antibodies that target an adenovirus protein; a single antibody mutation then makes them bind platelet factor 4 strongly, and a common immune gene variant shapes the response. VITT requires both a hereditary variant and a rare antibody mutation, explaining its rarity and offering clues for designing safer adenovirus-based vaccines in the future.

via ScienceAlert|
#adenovirus#antibodies#platelet-factor-4
Camelid Antibodies Offer New Hope for Alzheimer's Treatment
health9 months ago

Camelid Antibodies Offer New Hope for Alzheimer's Treatment

A new study suggests that nanobodies, small antibody-like proteins found in camelids like alpacas, could be developed into treatments for brain disorders such as Alzheimer's, offering potential advantages over traditional antibodies due to their size and ability to passively enter the brain, though further safety and efficacy testing is needed before clinical trials.

via Good News Network|
#alzheimers#antibodies#brain-disorders