Reversible Nonhormonal Male Contraception Edges Toward Reality
Cornell researchers demonstrated a proof-of-principle for nonhormonal, reversible male contraception by transiently halting sperm production in mice through disruption of meiosis with the small molecule JQ1. Fertility recovered after treatment ended, with most normal meiosis and healthy offspring upon breeding, suggesting a potential injectable or patch-based method for humans—though JQ1 itself isn’t suitable for human use due to side effects.