All articles tagged with #phenoage
Winners of the Longevity World Cup reduced their estimated biological ages (PhenoAge) by 20.1–22.1 years through a data-driven approach: careful diet, regular exercise, sleep optimization, and extensive biomarker tracking. Experts caution that PhenoAge is an estimate and can swing with short-term changes, but the winners emphasize consistent habits and monitoring health data over pills or quick fixes.
A UK Biobank study of 49,414 adults found filtered coffee linked to slower biological aging (lower PhenoAgeAccel and KDM-BAAccel, higher rLTL), while instant coffee associated with faster aging (higher PhenoAgeAccel and KDM-BAAccel, lower rLTL). Effects are small and influenced by covariates like smoking, BMI, and dairy/sugar adds; among those drinking more than three cups of instant coffee, older adults, men, and current smokers showed greater age-acceleration in some measures.
New cross-cohort study finds younger birth cohorts are biologically older than earlier generations at the same age, based on PhenoAge from blood biomarkers, and that higher age-gap scores are tied to greater risk of early-onset cancers (lung, digestive system, uterus) even after accounting for smoking, obesity, telomere length, and genetics, suggesting environmental influences on aging and potential for targeted prevention.
A new study finds people born in the 1990s have a larger gap between biological age and chronological age than those born earlier, especially men, suggesting accelerated aging that correlates with a higher risk of early-onset cancers (lung, colorectal, uterine, and more). Cancer in people under 50 rose 24% from 1990 to 2019, with colorectal cancers diagnosed before 55 increasing in the US from 11% to 20% of cases. Possible contributors include earlier puberty and rising obesity, diabetes and related factors; researchers note aging can vary by organ and environment and that more work is needed to pin down causes and prevention.
A UK study of more than 3,500 adults found that engaging in weekly arts or cultural activities (visiting museums, crafting, singing, etc.) is linked to slower biological aging across several epigenetic clocks. The DunedinPACE clock showed up to 4% slower aging for those with weekly activity, and PhenoAge suggested about a one-year younger biological age, with stronger effects in middle-aged adults, indicating arts participation may promote health similarly to regular exercise.