All articles tagged with #pp2a
In preclinical models, blocking the SET protein reactivates the tumor-suppressing enzyme PP2A, reducing glioblastoma growth and making cancer cells more sensitive to radiation, offering a potential way to enhance standard therapies; human trials are needed to assess safety and efficacy.
Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19 have been determined, shedding light on the molecular mechanisms of PP2A:B55 inhibition during mitotic entry. The structures reveal that ARPP19 and FAM122A bind to distinct regions of PP2A:B55, with ARPP19 binding in a tripartite manner involving three interaction sites. These findings provide valuable insights into the regulation of cell cycle progression and mitosis.