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Sigvotatug Vedotin

All articles tagged with #sigvotatug vedotin

Pfizer's New NSCLC ADC Flops in Phase 3, but Combinations Could Revive the Program
business2 months ago

Pfizer's New NSCLC ADC Flops in Phase 3, but Combinations Could Revive the Program

Pfizer’s first new ADC after acquiring Seagen failed to meet its primary endpoint in a phase 3 nonsquamous NSCLC trial, showing no significant overall survival advantage vs docetaxel. The company cites a stronger signal in a patient subgroup with one prior therapy and notes ongoing phase 3 studies combining sigvotatug vedotin with pembrolizumab in first-line NSCLC, sustaining optimism for the program despite the setback.

via Fierce Biotech|
#business#nsclc#pembrolizumab
Pfizer’s Sigvotatug Vedotin: No Overall Survival advantage in NSCLC Phase 3, but signals in one-prior-therapy patients
health2 months ago

Pfizer’s Sigvotatug Vedotin: No Overall Survival advantage in NSCLC Phase 3, but signals in one-prior-therapy patients

Pfizer reported topline Phase 3 SigVie-002 results in previously treated metastatic non-squamous NSCLC: sigvotatug vedotin did not significantly improve overall survival vs docetaxel in the overall population, but showed a stronger OS and PFS signal in patients with only one prior therapy; exploratory IB6 expression data were inconclusive; safety was manageable; results to be shared at a future medical congress, with ongoing first-line studies in combination with pembrolizumab.

via Business Wire|
#docetaxel#health#non-small-cell-lung-cancer