Tag

Solriamfetol

All articles tagged with #solriamfetol

health14 days ago•35 min saved

Dawn wakefulness drug could help pre-dawn workers stay alert

A NEJM Evidence trial found solriamfetol (Sunosi) improves wakefulness in early-morning workers with shift-work disorder, extending awake time by about 12.5 minutes on a full eight-hour shift versus placebo, with only modest side effects. This provides the first randomized evidence supporting a wakefulness drug for pre-dawn workers, and a follow-up trial in overnight workers is planned as a path toward formal labeling for shift-work disorder.

via Earth.com|

#early-morning #health #shift-work-disorder

health2 months ago•8 min saved

Wakefulness drug helps pre-dawn workers stay alert

A four-week randomized trial in 78 early-morning shift workers with shift work disorder found that solriamfetol (Sunosi) reduced daytime sleepiness, extended wakefulness during simulated eight-hour shifts, and improved self-reported functioning and work productivity; long-term safety is still unknown, and a follow-up study in overnight workers is planned to evaluate broader use.

via SciTechDaily|

#early-morning-shifts #health #nejm-evidence

health2 years ago•1 min saved

"Scientists Unveil Revolutionary Drug That Outperforms Espresso in Combating Daytime Sleepiness"

Scientists have discovered that three anti-fatigue drugs, including solriamfetol (brand name SUNOSI), are more effective than a placebo at reducing daytime sleepiness in people with obstructive sleep apnea. The drugs were found to improve wakefulness, with solriamfetol having the largest impact. However, potential side effects, such as increased blood pressure, should be considered. The study highlights the potential of these drugs as alternatives to caffeine for combating daytime sleepiness.

via Daily Mail|

#anti-fatigue-drugs #daytime-sleepiness #health

health2 years ago•3 min saved

Breakthrough Discovery: Non-Caffeine Drug Alleviates Daytime Sleepiness

Researchers have identified a drug called solriamfetol that shows promise in relieving excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). In a study reviewing 14 clinical trials, solriamfetol was found to be more effective than placebos in combating EDS. Two other anti-fatigue medications, armodafinil-modafinil and pitolisant, also showed some effectiveness. However, solriamfetol had the largest statistical difference in terms of wakefulness. The drugs' potential benefits and side effects, particularly in the long term, require further investigation. These medications may also be useful in treating related conditions such as chronic fatigue syndrome and long COVID. With the high prevalence of OSA globally, better treatments are urgently needed.

via ScienceAlert|

#drug-treatment #excessive-daytime-sleepiness #health

health2 years ago•2 min saved

"Groundbreaking Study Reveals Optimal Treatment for Daytime Sleepiness"

A study conducted by researchers from McMaster University has found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA), in addition to the standard positive airway pressure (PAP) mask treatment. The study, based on a comprehensive review of 14 clinical trials, suggests that solriamfetol, along with armodafinil-modafinil and pitolisant, can combat fatigue effectively. However, solriamfetol may raise blood pressure, which is a concern for OSA patients with cardiovascular issues. The researchers believe that these anti-fatigue medications could also be beneficial for related conditions such as chronic fatigue syndrome and long COVID.

via SciTechDaily|

#excessive-daytime-sleepiness #health #positive-airway-pressure-mask

health3 years ago•2 min saved

New Drug Outperforms Caffeine in Fighting Daytime Sleepiness.

Solriamfetol, a prescription drug, has emerged as a promising alternative to caffeine for promoting alertness, particularly in patients with Obstructive Sleep Apnea (OSA) and Excessive Daytime Sleepiness (EDS). Unlike caffeine, which inhibits adenosine receptors, solriamfetol increases the levels of dopamine and norepinephrine – neurotransmitters linked to wakefulness. Solriamfetol maintains wakefulness for as long as nine hours, requiring less frequent dosing and minimizing sleep disruption risk. However, it can cause side effects such as headache, nausea, and decreased appetite, and carries a risk of abuse and dependency.

via Giant Freakin Robot|

#alertness #caffeine #health

health3 years ago•3 min saved

New Drug Discovered to Combat Daytime Sleepiness Without Caffeine

Researchers have identified three anti-fatigue medications that can help combat excessive daytime sleepiness (EDS) for people with obstructive sleep apnea (OSA). Solriamfetol was found to be the most effective in reducing EDS, followed by armodafinil-modafinil and pitolisant. However, side effects could be an issue with some of the medications. The drugs could also be helpful in treating related illnesses such as chronic fatigue syndrome and long COVID. As many as a billion people globally are affected by OSA, highlighting the need for better treatments.

via ScienceAlert|

#chronic-fatigue-syndrome #health #long-covid