Coffee Activates an Ancient Cellular Energy Switch Linked to Longevity
A study in fission yeast finds caffeine activates the energy sensor AMPK via components like Ssp1/Ssp2/Amk2, reprogramming metabolism and stress responses, accelerating mitosis and extending lifespan under non-dividing conditions; the effect is indirect, not through TORC1, and aligns caffeine with aging pathways also targeted by therapies such as metformin; a 2026 bioRxiv follow-up highlights Bro1's role linking TOR signaling to cellular maintenance and longevity.