All articles tagged with #tranexamic acid
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A study conducted by the London School of Hygiene & Tropical Medicine (LSHTM) has shown that tranexamic acid (TXA), a drug used to treat severe postpartum bleeding, can be safely administered intramuscularly and orally. The intramuscular route reaches therapeutic levels quickly and is well-tolerated, making it a potential alternative to intravenous administration, particularly in low and middle-income countries where healthcare facilities may be limited. Oral TXA is also well-tolerated but takes longer to reach therapeutic blood concentrations, making it less suitable for emergency treatment. Severe postpartum bleeding is a leading cause of maternal death globally, and these findings could pave the way for more accessible and effective treatment options. Comparative Phase 3 clinical trials are set to begin in August to further evaluate the effectiveness of intramuscular administration in reducing postpartum bleeding.
Tranexamic acid, a drug that slows the natural breakdown of blood clots, does not appear to be more effective than a placebo in reducing the need for blood transfusion or preventing maternal death in patients with increased risk for excessive bleeding because of cesarean delivery, according to a study funded by the National Institutes of Health. The study included 11,000 patients from 31 birthing centers across the United States and found no benefit of the drug, compared to placebo. However, patients who received tranexamic acid had slightly less need for additional medical or surgical interventions to treat postpartum hemorrhage and a slightly lower drop in red blood cell count.