Tag

Clinical Trials

All articles tagged with #clinical trials

health5 days ago•9 min saved

High-Dose IV Vitamin C Reemerges as a Potential Cancer Therapy

Very high-dose vitamin C given intravenously can reach blood levels far beyond what tablets achieve, where it may generate hydrogen peroxide that selectively damages cancer cells while sparing normal cells; early trials show mixed results—potential improvements in quality of life and some signals of benefit alongside standard treatments, but no definitive survival advantage yet, making it experimental and appropriate only within clinical trials or supervised settings, not as a general cancer cure.

via SciTechDaily|

#cancer #clinical-trials #health

health7 days ago•19 min saved

Ketamine–buprenorphine combo may rapidly reduce suicide risk in depression

A new study suggests a single ketamine infusion followed by low-dose buprenorphine can quickly and durably reduce suicidal ideation in adults with major depressive disorder, though longer-term safety and effectiveness remain uncertain.

via The Washington Post|

#buprenorphine #clinical-trials #depression

health11 days ago•22 min saved

MS patient credits diet-based regimen with reversing disability, fueling debate on functional medicine

Terry Wahls, a physician diagnosed with MS, says a paleo-style diet, targeted supplements, exercise, and other lifestyle changes reversed her disability, propelling her into a central role in the functional medicine movement. The piece traces her decline under conventional MS therapies, her self-directed diet-and-lifestyle approach (the Wahls Protocol), and small studies noting fatigue and functional improvements, while noting that larger, rigorous trials are limited and critics warn against overinterpreting limited data or conflating correlation with causation. It also explores the broader commercial and clinical debate over root-cause therapies, microbiome testing, and the balance between innovation and evidence.

via Straight Arrow News - SAN|

#clinical-trials #diet-and-nutrition #functional-medicine

healthcare12 days ago•2 min saved

Regenxbio hits milestone in Duchenne gene therapy ahead of FDA filing

Regenxbio announced its experimental Duchenne muscular dystrophy gene therapy produced sufficient levels of a miniaturized muscle protein in a clinical trial, paving the way for an FDA submission and aiming to improve on Sarepta’s Elevidys in both efficacy and safety, amid ongoing safety concerns surrounding the competitor.

via statnews.com|

#biotechnology #clinical-trials #duchenne-muscular-dystrophy

health19 days ago•6 min saved

KRAS-targeting pancreatic cancer drug daraxonrasib could redefine treatment

A new pancreatic cancer drug, daraxonrasib, paired with chemotherapy, nearly doubles survival in advanced disease. In Phase 3, overall survival was 13.2 months with the combo vs 6.7 months with chemo alone, and earlier data showed progression-free survival around 8 months at the highest dose. The FDA has fast-tracked the drug and allowed expanded access, with potential use beyond KRAS-mutant tumors and possible earlier-line therapy consideration.

via NBC News|

#clinical-trials #daraxonrasib #health

health22 days ago•12 min saved

Africa’s Disease Burden Remains Invisible in Global Clinical Trials

Africa carries about a quarter of the global disease burden and around 20% of the population, yet its communities are underrepresented in leading randomized trials. An analysis of 2,472 trials from 2019–2024 found only 3.9% conducted exclusively in Africa, with just 0.6% of major cardiovascular trials Africa-only. This underrepresentation undermines external validity and the applicability of results to African populations, while infectious diseases still dominate Africa-based research even as non-communicable diseases rise. The piece argues for Africa-led research, ring-fenced funding, regional trial networks, and better reporting of trial diversity to align global medical knowledge with Africa’s health reality.

via The Conversation|

#africa #clinical-trials #health

science24 days ago•9 min saved

Decoding Ketamine: Low-dose drug combos aim for rapid, safer antidepressant effects

Two studies reveal how ketamine triggers rapid antidepressant effects by briefly silencing interneuron brakes in the prefrontal cortex via mu-opioid receptors, and show that a low-dose three-drug combo can replicate this benefit with fewer side effects; longer-lasting relief depends on TrkB and mGluR5 receptor cross-talk driven by BDNF, which strengthens and stabilizes synapses. Researchers plan accelerated clinical trials using safe, existing drugs to translate these findings into patient treatments.

via Neuroscience News|

#clinical-trials #depression #ketamine

health25 days ago•21 min saved

FDA expands access to potential pancreatic cancer breakthrough amid review

The FDA granted expanded access to Revolution Medicines’ pancreatic cancer drug daraxonrasib, allowing more patients to use the treatment while it remains under regulatory review. In trials the drug showed promise, including doubling survival time in some studies, raising hopes that approval could come later in the year.

via The Washington Post|

#cancer #clinical-trials #fda

health25 days ago•15 min saved

Psilocybin-assisted therapy shows potential to help people quit smoking

A BBC Health report describes a randomized trial where a single high dose of psilocybin (about 30 mg, with 10 CBT sessions) plus talk therapy led to significantly higher smoking cessation than nicotine patches: 52% abstinent at six months in 82 participants vs 25% in the patch group. These findings, echoing earlier smaller studies, suggest psychedelics can trigger neuroplastic changes and a shift in priorities that support quitting, and are driving a larger NIH-funded, multi-site follow-up study to confirm efficacy and understand mechanisms. However, experts caution the sample was small and not highly diverse, so results may not generalize, and long-term safety and durability remain to be seen.

via BBC|

#clinical-trials #health #neuroplasticity

health25 days ago•3 min saved

A New Era in Women’s Health: Menopause Care Shifts Toward Individualized Treatment and Inclusive Research

As the U.S. nears its 250th anniversary, a WTOP series highlights how menopause care is moving from early 2000s fear of HRT to personalized therapy guided by updated FDA risk–benefit guidance, with increasing emphasis on sex‑specific, inclusive research (NIH policy and a 2024 executive order) and broader attention to how hormonal changes affect both general and oral health.

via WTOP|

#clinical-trials #fda #health

health27 days ago•5 min saved

GLP-1 diabetes medicines show potential to curb Alzheimer's protein buildup in preclinical studies

A new review of mostly preclinical studies links GLP-1 diabetes/weight-loss medications (e.g., semaglutide, liraglutide) to reduced amyloid-beta plaques and tau tangles in cells and animals, with only two small human trials reporting mixed results; still early evidence and larger clinical trials are needed to confirm cognitive benefits.

via ScienceAlert|

#alzheimers-disease #amyloid-beta #clinical-trials

health-policy27 days ago•2 min saved

FDA Gears Up Real-Time Trials Fueled by AI to Accelerate Drug Development

The FDA will speed drug development by reviewing real-time trial data from AstraZeneca and Amgen and is seeking public input on a pilot using AI to improve safety monitoring, dosing, and recruitment. The efforts include AZ’s Phase 2 lymphoma trial at MD Anderson and UPenn, and Amgen’s Phase 1b small cell lung cancer study, all supported by Paradigm Health’s real-time data platform.

via statnews.com|

#artificial-intelligence #astrazeneca #clinical-trials

health1 month ago•7 min saved

Vaccinated high-risk COVID outpatients see no hospitalization benefit from Paxlovid, but recover faster

Two open-label randomized trials in the UK (PANORAMIC) and Canada (CanTreatCOVID) found that early Paxlovid (nirmatrelvir–ritonavir) did not reduce hospitalizations or deaths among vaccinated high-risk outpatients, though it shortened time to recovery and lowered viral load. Adverse events were common and one trial stopped early due to slow recruitment and Paxlovid supply. Experts caution against overinterpreting the findings, suggesting antivirals may still be useful on a case-by-case basis in older or immunocompromised individuals or where rapid recovery is a priority.

via CIDRAP|

#antivirals #clinical-trials #covid-19

health1 month ago•3 min saved

FDA Accelerates Development and Access to Psychedelic Mental Health Treatments After Executive Order

Following a presidential executive order, the FDA announced actions to speed development and access to treatments for serious mental illness, including national priority vouchers for psilocybin in treatment-resistant depression and major depressive disorder and for PTSD treated with methylone, approval of an early-phase study of noribogaine hydrochloride for alcohol use disorder (the first U.S. trial of an ibogaine derivative), and imminent final guidance to shape serotonin-2A agonist trials—emphasizing rigorous science and safety, especially for veterans.

via fda.gov|

#clinical-trials #fda #health

health1 month ago•19 min saved

Moderna kicks off bird flu mRNA vaccine trial as funding dries up

Moderna is launching a large-scale human trial of an mRNA vaccine for H5N1 bird flu after the Department of Health and Human Services canceled hundreds of millions in funding for vaccine development, signaling a shift in U.S. pandemic preparedness.

via The Washington Post|

#bird-flu #clinical-trials #health