Tag

Clinical Trials

All articles tagged with #clinical trials

health2 days ago•4 min saved

Creatine Shows Early Hints for Depression Treatment, but Evidence Is Not Conclusive

A Brain Medicine review of five randomized trials (n=238) finds mixed evidence that creatine helps depression: two trials in women with major depressive disorder showed meaningful improvement when creatine was added to antidepressants or cognitive behavioral therapy, while other studies in non-responders, adolescent girls, and bipolar depression showed no benefit. Safety concerns emerged in bipolar patients who developed hypomania/mania. The researchers caution that small sample sizes, mostly female participants, and varying study quality limit conclusions and call for larger, longer trials to determine efficacy, optimal dosing, and potential synergy with exercise; the findings suggest creatine is an intriguing possibility, not a proven treatment yet.

via SciTechDaily|

#brain-energy #clinical-trials #creatine

health3 days ago•5 min saved

Creatine as Depression Add-On Shows Early Promise, But Not Definitive

A review of five randomized trials suggests creatine monohydrate may help depressive symptoms when added to standard treatments like antidepressants or cognitive-behavioral therapy, but the evidence is inconsistent and not yet enough to change clinical practice. Some studies saw improvement (e.g., 5 g/day with escitalopram; another with CBT), while others showed no benefit (teen girls, bipolar depression). Researchers caution that creatine appears safe but should complement—not replace—standard care, and larger trials are needed to identify who may benefit most.

via New York Post|

#clinical-trials #creatine #depression

health3 days ago•12 min saved

Small lifestyle tweaks, big questions: can we truly slow dementia?

Ambitious trials like FINGER and POINTER show that intensive diet, exercise, and social/cognitive programs can yield small cognitive benefits and may modestly slow cognitive ageing, but they have not proven a reduction in dementia incidence. The Lancet Commission lists 14 modifiable risk factors and estimates that up to 45% of global dementia cases could be theoretically preventable, yet translating that into personal risk reduction is uncertain and many factors lie outside individual control. While results are consistently modest and questions about scalability remain, researchers and policymakers continue to weigh the potential brain-health gains against practical challenges as WHO guidelines on risk reduction approach release.

via Nature|

#aging #brain-health #clinical-trials

health8 days ago•24 min saved

Creatine Shows Mood-Boosting Hints in Depression, but Big Caveats Remain

A Brain Medicine review of six randomized trials (238 participants) finds mixed evidence that creatine, a brain-energy booster, can help depression: some small studies show benefit in women with major depressive disorder when added to escitalopram or CBT, others show no effect, and a bipolar-depression trial raised safety concerns about mood switching. The studies are small and heterogeneous, so researchers urge larger, longer trials across diverse groups and testing creatine with established treatments; creatine is not yet a proven depression treatment.

via ZME Science|

#bipolar-disorder #clinical-trials #creatine

health10 days ago•3 min saved

Regenerative Joint Therapies Reversing Osteoarthritis in Weeks, Aiming for Human Trials

Colorado researchers report two regenerative therapies that reversed osteoarthritis signs in animals within 4–8 weeks: an injectable drug-delivery system using a repurposed FDA-approved drug and a biomaterial that recruits body-progenitor cells to repair cartilage. Backed by ARPA-H’s NITRO program with up to $33.5 million, the team has moved from phase one to phase two, with potential human trials in about 18 months and plans for commercial development through Renovare Therapeutics.

via ScienceDaily|

#arpa-h #clinical-trials #health

health10 days ago•4 min saved

Creatine's Emerging Link to Depression: Encouraging Signals, Uncertain Proof

A Brain Medicine review of five randomized trials (238 participants) found mixed results: two studies in women with major depressive disorder showed added benefits when creatine was used with antidepressants or with cognitive behavioral therapy, while three other trials found no significant improvement. Bipolar patients showed possible safety concerns with hypomania/mania. Due to small sizes and methodological differences, the evidence is not strong enough to recommend creatine for depression, highlighting the need for larger, longer trials and exploration of dosing and combination with exercise.

via ScienceDaily|

#brain-energy #clinical-trials #creatine

sports10 days ago•2 min saved

ALS rallying cry: Chris Johnson’s diagnosis fuels Tim Shaw’s fight

Former NFL running back Chris Johnson revealed he has ALS, a disclosure that has given Tim Shaw renewed hope in his own battle with the disease. Shaw credits Johnson’s positive attitude and pursuit of treatments—recent therapies and ongoing clinical trials—for lifting him out of survival mode and motivating him to push forward alongside other NFL veterans advocating for ALS research.

via NBC Sports|

#als #chris-johnson #clinical-trials

health16 days ago•4 min saved

US Expands Ebola Fight by Supplying Experimental Drug for Congo Trials

The U.S. is providing stockpiled doses of Mapp Biopharmaceutical’s experimental MBP134 antibody for compassionate use in the Democratic Republic of Congo and to help run a WHO-coordinated clinical trial, marking the first direct U.S. involvement in testing this therapy as part of broader Ebola response efforts amid the Bundibugyo outbreak; trials of MBP134 and Gilead antivirals are planned in coming weeks.

via NBC News|

#clinical-trials #congo #ebola

health18 days ago•8 min saved

HHS Unveils Bold Plan to Reclaim U.S. Leadership in Clinical Trials

The Department of Health and Human Services today launched a department-wide effort to restore U.S. leadership in clinical research, accelerate drug development, and expand patient access to innovative therapies. Key moves include FDA pilots to shorten early-trial timelines and clarify expectations, NIH support for AI-enabled, well-powered trials, NCATS’ translational advances, NCI’s streamlined trial activation and enrollment, ONC’s patient-trial matching via electronic health records, and ARPA-H initiatives to modernize research—all aimed at reducing delays and strengthening domestic biomedical leadership.

via HHS.gov|

#arpa-h #clinical-trials #fda

health-policy18 days ago•2 min saved

FDA launches pilot to speed up early drug trials and bolster U.S. competitiveness

The FDA announced a pilot to accelerate early-stage clinical trials, aiming to cut development time by six to 12 months, boost U.S.-based trials, and counter China, while seeking congressional support to establish a permanent, faster Investigational New Drug pathway in the 2027 budget; the effort follows advocacy by former FDA Commissioner Marty Makary.

via statnews.com|

#clinical-trials #drug-development #fda

health-news29 days ago•8 min saved

Georgia hospitals launch trials of a promising pancreatic cancer drug

Researchers at Emory University’s Winship Cancer Institute and Piedmont Atlanta Hospital are testing daraxonrasib, an experimental pancreatic cancer drug, after FDA early-access approval; early results show tumor shrinkage with fewer side effects than standard chemotherapy, offering hope for patients facing one of the deadliest cancers.

via Atlanta Journal-Constitution|

#clinical-trials #emory-university #health-news

science1 month ago•34 min saved

Alzheimer's preclinical stage reveals three distinct cognitive decline paths

New analysis of 1,629 older adults tracked for up to seven years identifies three cognitive trajectories in preclinical Alzheimer's: stable, slow decline, and fast decline, with about 70% remaining stable over about six years. Baseline biomarkers—higher p-tau217, greater tau burden on brain scans, and smaller hippocampus—predicted faster decline, while the APOE ε4 allele also increased risk. Amyloid presence mattered but was a weaker predictor than tau and brain structure. The findings suggest clinical trials in preclinical Alzheimer's should target likely decliners to improve efficiency, since enrolling many stable individuals can dilute a treatment effect. Predictions are probabilistic, not exact, and researchers call for more biomarkers and refined models to guide trials and prognosis.

via PsyPost|

#alzheimers-disease #biomarkers #clinical-trials

science1 month ago•2 min saved

Tooth Regrowth Nears Human Trials as Toregem Secures Funding

Toregem Biopharma has raised about $5.3 million to accelerate a drug-based approach that inhibits USAG-1, with plans for a Phase 2 trial in Japan to grow teeth from patients’ own tissue. Building on mouse studies and early human safety data, the company targets a potential market around 2030, but experts caution it may be limited to children due to available dental epithelial cells and could risk uncontrolled tooth growth elsewhere; whether it will work in humans remains uncertain.

via Futurism|

#clinical-trials #regenerative-dentistry #science

business1 month ago•2 min saved

NewLimit raises $435M to launch its first liver-focused clinical trial

NewLimit, a South San Francisco longevity biotech, secured $435 million in a Series C led by Founders Fund (with Thrive Capital, Lilly Ventures, Nat Friedman, and Daniel Gross) valuing the company at about $3.1 billion as it moves toward its first liver-focused clinical trial. Founders include Brian Armstrong, Blake Byers, and Jacob Kimmel, with prior rounds of $130 million in May 2025 and $45 million in October 2025.

via statnews.com|

#biotech-startups #biotechnology #business

health1 month ago•3 min saved

NHS Galleri trial misses its main goal on late-stage cancer reduction

Results from the UK's largest randomized trial of the Galleri multi-cancer blood test showed no statistically significant reduction in late-stage cancers (stages 3–4) when added to standard screening; while a secondary look at stage-4 cancers suggested a 14% reduction, mortality outcomes are still pending.

via The Guardian|

#cancer #clinical-trials #grail