Evolution of Single-Cell 3D Genomes in Kras-Driven Cancers
TL;DR
This study uses in situ single-cell chromatin tracing to map 3D genome changes during Kras-driven lung and pancreatic cancers, revealing stage-specific conformational alterations that can distinguish cancer states, identify prognostic genes, and uncover regulators like Rnf2 that influence genome architecture and tumor progression.
Topics:healthcancer-research#3d-genome-organization#cancer-biomarkers#cancer-research#chromatin-tracing#lung-adenocarcinoma#single-cell-genomics
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