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Single Cell Genomics

All articles tagged with #single cell genomics

New Genomic Maps Reveal How Trophoblasts Engineer the Maternal-Fetal Interface
science7 days ago

New Genomic Maps Reveal How Trophoblasts Engineer the Maternal-Fetal Interface

A new review in Nature Reviews Genetics synthesizes recent advances in single-cell and spatial genomics to explain how fetal trophoblast cells regulate gene expression to build and maintain the maternal-fetal interface. The article details how these cells differentiate into specific subtypes, remodel maternal blood vessels, and modulate the immune system to support fetal growth while protecting the mother. It highlights how these technologies, combined with in vitro models, are helping researchers understand the causal mechanisms behind healthy pregnancy and complications like preeclampsia.

via Nature|
#gene-regulation#maternal-fetal-interface#placental-biology
PsychAD Consortium Maps 6.3 Million Brain Cells to Link Genetic Risk with Cellular Disease Mechanisms
science25 days ago

PsychAD Consortium Maps 6.3 Million Brain Cells to Link Genetic Risk with Cellular Disease Mechanisms

A coordinated series of nine papers led by the PsychAD Consortium has released the largest single-cell transcriptomic atlas of the human brain to date. The primary study, published in Nature, analyzes over 6.3 million nuclei from 1,494 donors to map molecular changes across eight brain disorders, including Alzheimer’s, Parkinson’s, and schizophrenia. The research identifies shared cellular vulnerabilities across diseases, particularly in immune and vascular cells, while distinguishing specific signatures for neurodegenerative versus psychiatric conditions. Complementary studies link genetic risk variants to specific cell types and develop AI frameworks for personalized Alzheimer’s progression. The findings suggest that while many brain disorders share common molecular pathways, distinct cellular responses drive individual disease trajectories, offering new targets for therapeutic intervention.

via Nature|
#alzheimers-disease#genetics#neuroscience
Unveiling Disease-Altered Cell States with Healthy Single-Cell References
science-and-technology3 years ago

Unveiling Disease-Altered Cell States with Healthy Single-Cell References

Precise identification of cell phenotypes altered in disease can provide valuable insights into pathogenesis, biomarkers, and potential drug targets. The selection of a healthy reference dataset is crucial for accurate analysis. This study compared the use of an atlas dataset and a control dataset as references for identifying disease-associated cell states. The results showed that combining both datasets (ACR design) led to sensitive detection of disease-specific cell states and reduced false positives. The ACR design was robust to variations in the size and composition of the reference datasets. The benefits of using an atlas dataset were demonstrated in the identification of interferon-stimulated states in patients with COVID-19.

via Nature.com|
#cell-states#covid-19#disease-identification
Cracking the Code: Placenta Project Reveals Secrets of Human Cells.
science-and-technology3 years ago

Cracking the Code: Placenta Project Reveals Secrets of Human Cells.

The Human Cell Atlas (HCA) project, launched in 2016, has enabled researchers to uncover the secrets of the placenta, the temporary organ that supports the unborn child. Understanding the mechanics of its functioning is crucial in ensuring healthy and viable pregnancies. The HCA project has also revealed cellular secrets of the immune system, brain, lungs, and other organs, discovering thousands of new types of cells in humans. The project uses single-cell genomics to sequence and characterise individual cells in tissue samples, enabling the identification of rare cells that are crucial in ensuring the proper functioning of organs in the body.

via The Guardian|
#cell-types#human-cell-atlas#placenta