Tag

Single Cell Genomics

All articles tagged with #single cell genomics

science21 days ago•12 min saved

Aging as a Program: Remodeling the Cell Society Across Life

A study analyzing 21 million mouse cells across five ages argues aging is a staged, programmed remodeling of the body's cell populations, not random molecular decay. Specific cell types rise or fall in defined windows—early loss of fat, muscle, and some brain progenitors; midlife depletion of tissue-support cells and immune components; later expansion of aging-associated immune cells—with genomic regions opening or closing in a coordinated pattern. These signals hint at upstream programs driving aging, echoed by midlife protein changes in humans. The work suggests aging begins before age 30 and that slowing it may require early interventions targeting vulnerable cell types and their signaling pathways.

via Quanta Magazine|

#aging #cell-biology #developmental-biology

health-and-medicine1 year ago•68 min saved

Mapping the Human Subcutaneous Adipose Tissue Genome and Methylome

This study provides a comprehensive single-cell epigenomic atlas of human subcutaneous adipose tissue, revealing cell-type-specific DNA methylation, chromatin conformation, and gene expression patterns, and their implications for obesity-related genetic risks and regulatory mechanisms.

via Nature|

#adipose-tissue #dna-methylation #epigenomics

cancer-research1 year ago•78 min saved

Evolution of Single-Cell 3D Genomes in Kras-Driven Cancers

This study uses in situ single-cell chromatin tracing to map 3D genome changes during Kras-driven lung and pancreatic cancers, revealing stage-specific conformational alterations that can distinguish cancer states, identify prognostic genes, and uncover regulators like Rnf2 that influence genome architecture and tumor progression.

via Nature|

#3d-genome-organization #cancer-biomarkers #cancer-research

science-and-technology2 years ago•69 min saved

Unveiling Disease-Altered Cell States with Healthy Single-Cell References

Precise identification of cell phenotypes altered in disease can provide valuable insights into pathogenesis, biomarkers, and potential drug targets. The selection of a healthy reference dataset is crucial for accurate analysis. This study compared the use of an atlas dataset and a control dataset as references for identifying disease-associated cell states. The results showed that combining both datasets (ACR design) led to sensitive detection of disease-specific cell states and reduced false positives. The ACR design was robust to variations in the size and composition of the reference datasets. The benefits of using an atlas dataset were demonstrated in the identification of interferon-stimulated states in patients with COVID-19.

via Nature.com|

#cell-states #covid-19 #disease-identification

science-and-technology3 years ago•4 min saved

Cracking the Code: Placenta Project Reveals Secrets of Human Cells.

The Human Cell Atlas (HCA) project, launched in 2016, has enabled researchers to uncover the secrets of the placenta, the temporary organ that supports the unborn child. Understanding the mechanics of its functioning is crucial in ensuring healthy and viable pregnancies. The HCA project has also revealed cellular secrets of the immune system, brain, lungs, and other organs, discovering thousands of new types of cells in humans. The project uses single-cell genomics to sequence and characterise individual cells in tissue samples, enabling the identification of rare cells that are crucial in ensuring the proper functioning of organs in the body.

via The Guardian|

#cell-types #human-cell-atlas #placenta