HMGN1's Role in Heart Defects in Down Syndrome
TL;DR
The study identifies HMGN1 as a dosage-sensitive gene on chromosome 21 that influences heart defects in Down syndrome, demonstrating that its increased expression reprograms heart cell identity and that reducing its dosage in mouse models rescues cardiac abnormalities.
Topics:healthhealth-and-medicine#cardiac-development#chromosomal-genes#down-syndrome#health-and-medicine#heart-defects#hmgn1
- Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21 Nature
- Nuclear binding protein identified as key contributor to trisomy 21-related CHDs News-Medical
- Exploring Chromosomal Genes Linked to Heart Disease BIOENGINEER.ORG
- Overactive HMGN1 May Underlie Heart Defects in Down Syndrome Genetic Engineering and Biotechnology News
- HMGN1 gene linked to heart problems in people with Down syndrome News-Medical
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