Tag

Health And Medicine

All articles tagged with #health and medicine

health-and-medicine3 hours ago•4 min saved

One Sauna Session Briefly Boosts Immune Cells in Blood

A 30-minute sauna session with a mid-way cold shower temporarily increases all circulating white blood cell types, including neutrophils and lymphocytes, peaking during heat exposure and returning to baseline about 30 minutes after the session ends. The rise likely reflects mobilization of immune cells from tissues—a mechanism similar to exercise that could enhance immune surveillance—though cytokine changes were small and long-term effects remain unknown. The study involved 51 adults and was published in Temperature, focusing on immediate, not lasting, immune responses.

via ScienceDaily|

#health-and-medicine #immune-system #lymphocytes

health-and-medicine16 hours ago•7 min saved

Alzheimer’s sleep breakthrough: brain immune cells offer new therapeutic angle

UK researchers report that brain immune cells called microglia drive sleep loss in Alzheimer’s; in a mouse model, turning off microglia restored about two hours of restorative sleep and could help detect early disease and slow progression, signaling a shift from neuron-focused treatments toward targeting microglia with future human trials.

via Lexington Herald Leader|

#alzheimers #biomarker #health-and-medicine

health-and-medicine1 day ago•6 min saved

Metformin's brain action unveiled: Rap1 in the hypothalamus lowers blood sugar

Researchers find metformin lowers blood sugar by acting in the brain, specifically by suppressing Rap1 in the ventromedial hypothalamus to activate SF1 neurons. These effects occur at tiny brain doses, suggesting a brain pathway adds to the drug’s known liver and gut actions and could inspire new diabetes therapies and broadened understanding of metformin’s brain benefits.

via ScienceDaily|

#diabetes #health-and-medicine #metformin

health-and-medicine1 day ago•7 min saved

RNA-targeting CRISPR revives immune visibility of prostate cancer

Researchers used an RNA-targeting CRISPR-Cas13 tool to lengthen the SPSB1 mRNA in prostate cancer cells, lowering SPSB1 protein levels and restoring the MHC-I immune signal. This made tumors more recognizable to T cells, enhancing immune checkpoint therapy in mice with no detectable off-target effects, and potentially extending to other immune-cold cancers.

via ScienceDaily|

#crispr #health-and-medicine #immunotherapy

health-and-medicine1 day ago•7 min saved

Microglial switch may decide Alzheimer's dementia risk

A human-donor study links a pivotal shift in brain microglia—the immune cells that respond to amyloid plaques and tau—to whether Alzheimer's pathology progresses to dementia, suggesting therapies that preserve beneficial microglial states and target their transition timing.

via ScienceDaily|

#alzheimers-disease #amyloid-b-plaques #dementia

health-and-medicine2 days ago•6 min saved

Daily prebiotic fiber reduces knee OA pain and strengthens grip

A six-week randomized trial in 117 adults with knee osteoarthritis found daily inulin, a prebiotic fiber, reduced pain and improved grip strength and pain sensitivity, with a notably lower dropout rate than a digital physiotherapy program, highlighting a possible gut–muscle–pain link and a simple, easy-to-maintain therapy option.

via ScienceDaily|

#gut-microbiome #health-and-medicine #inulin

health-and-medicine3 days ago•6 min saved

Sulfur compound unlocks stronger HGF signaling to boost aging muscle repair

Kyushu University researchers report that lipoic acid trisulfide (LASSS), a sulfur-based antioxidant, can bind to hepatocyte growth factor (HGF) and enhance its interaction with the c-Met receptor while reducing nitration. This creates a more active form of HGF—dubbed a potential “Super HGF”—that strengthens muscle repair in aging. In lab tests and a mouse model of muscle atrophy, LASSS improved HGF signaling and resisted damage much more effectively than glutathione trisulfide (GSSSG). While promising for preserving muscle health during aging or inactivity, further in vivo safety and efficacy studies are needed before considering human use.

via ScienceDaily|

#aging #antioxidants #health-and-medicine

health-and-medicine4 days ago•7 min saved

Gel Rebuilds Tooth Enamel Without Fluoride

Researchers at the University of Nottingham developed a fluoride-free, protein-based gel that coats damaged enamel, guides calcium and phosphate from saliva to form orderly new mineral crystals, potentially repairing eroded enamel, reducing sensitivity, and enabling new dental products with commercialization planned through the startup Mintech-Bio.

via ScienceDaily|

#biomimetic #dentistry #enamel

health-and-medicine4 days ago•6 min saved

Plant-derived compound slows rheumatoid arthritis in rats by rebalancing fatty acid metabolism

A plant-derived compound called obakulactone (OL) alleviates arthritis symptoms and joint damage in a rat model of RA by promoting ACOT1 degradation via the ubiquitin–proteasome pathway, correcting disrupted unsaturated fatty acid metabolism, and modulating immune cells and inflammatory signals. The study identifies ACOT1 as a potential drug target and suggests a new preclinical strategy for RA, though its safety and efficacy in humans remain to be tested.

via ScienceDaily|

#acot1 #fatty-acid-metabolism #health-and-medicine

health-and-medicine6 days ago•7 min saved

Midlife TV binge may foreshadow later brain changes, USC study finds

A USC-led study of about 1,700 adults found that watching TV very often in midlife is linked to smaller brain regions involved in memory and decision-making and more white-matter damage decades later, independent of overall sitting time. In contrast, long hours of mentally engaging sitting jobs did not show the same pattern, suggesting the content of sedentary time matters. The effects were more pronounced in men. Limitations include self-reported TV viewing and lack of baseline MRI data. Researchers suggest doctors may eventually advise reducing TV time and choosing cognitively engaging activities to protect brain health.

via ScienceDaily|

#brain-health #health-and-medicine #midlife

health-and-medicine6 days ago•5 min saved

Novel human antibody stalls spread of aggressive prostate cancer in preclinical study

Researchers at Umeå University and collaborators developed a fully human antibody that stopped growth and metastatic spread of an aggressive prostate cancer in preclinical tests, via a newly identified mechanism that may carry a lower risk of side effects. While promising, the therapy requires further safety studies and regulatory approval before clinical use, and researchers plan to explore its potential against other solid tumors.

via ScienceDaily|

#cancer-therapy #health-and-medicine #metastasis

health-and-medicine10 days ago•6 min saved

Alzheimer's drug fixes DNA damage and dampens brain inflammation in mice

King's College London researchers report that KCL-286, a drug originally developed for spinal cord injury, repaired DNA double-strand breaks and reduced brain inflammation in a mouse model of Alzheimer's, attacking multiple early disease pathways beyond amyloid and tau. Since it has already cleared Phase 1 safety testing for another condition, it could move more quickly into Alzheimer's clinical testing.

via ScienceDaily|

#alzheimers-disease #dna-damage-repair #health-and-medicine

health-and-medicine14 days ago•7 min saved

Gum-Disease Bacteria May Drive Calcified Heart Valve Damage, New Research Finds

Researchers traced Porphyromonas gingivalis, a gum-disease bacterium, to calcific aortic valve stenosis by showing it can accumulate in the aortic valve and drive inflammation and calcium buildup in mice; antibiotics reduced the effect, and deleting IL-1β lessened calcification, hinting at a biological link between periodontal disease and heart valve damage. The findings are preliminary (not yet peer-reviewed) and human studies are underway, but experts say good oral health could benefit heart health.

via ScienceDaily|

#calcific-aortic-valve-stenosis #gum-disease #health-and-medicine

health-and-medicine14 days ago•6 min saved

Two neuron surface proteins may drive Parkinson's spread; blocking them slows disease in mice

Yale researchers identified two neuron surface proteins, mGluR4 and NPDC1, that help misfolded α-synuclein enter healthy neurons and drive Parkinson's progression; genetically blocking either protein in mice reduced spread and symptoms, pointing to a new therapeutic target to slow the disease.

via ScienceDaily|

#alpha-synuclein #health-and-medicine #mglur4

health-and-medicine16 days ago•7 min saved

DT-109 Reverses Severe Fatty Liver Disease by Repairing the Gut Barrier

An experimental glycine-based tripeptide called DT-109 reversed severe metabolic dysfunction–associated steatohepatitis (MASH) in animal studies by strengthening the gut barrier and lowering intestinal ammonia, disrupting the harmful gut-to-liver inflammatory loop; findings in mice and nonhuman primates point to a new gut-targeted therapy approach for MASH, with clinical trials needed to assess safety and effectiveness in people.

via ScienceDaily|

#dt-109 #fatty-liver-disease #gut-barrier