ABCA7 Variants Affect Neuronal Phosphatidylcholine and Mitochondria
TL;DR
Variants causing loss of function in ABCA7 are linked to Alzheimer's risk by disrupting lipid transport, mitochondrial function, and cellular stress responses in neurons; treatment with CDP-choline can reverse these effects, highlighting potential therapeutic strategies.
Topics:healthhealth-and-science#abca7#alzheimers-disease#health-and-science#lipid-metabolism#mitochondria#neurons
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