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Alzheimers Disease

All articles tagged with #alzheimers disease

Healthy Plant Diets Linked to Lower Dementia Risk, Even in Later Life

Healthy Plant Diets Linked to Lower Dementia Risk, Even in Later Life

A large multiethnic study of about 93,000 adults found that higher-quality plant-based diets are linked to lower dementia risk: those eating more plant foods had about 12% lower risk, while those following a healthy plant-based pattern had about 7% lower risk; conversely, unhealthy plant-based eating raised risk. Importantly, changing to a healthier plant-based diet over 10 years reduced dementia risk by 11% (shifting toward unhealthy patterns increased risk by 25%). Benefits appeared even in people over 60 at baseline, suggesting late-life dietary improvements can help. The study is observational, so it shows associations, not causation, and researchers call for interventional trials to confirm causality.

Rethinking Alzheimer’s: A multi-target battle plan
health-and-medicine4 hours ago

Rethinking Alzheimer’s: A multi-target battle plan

Alzheimer’s is viewed as a complex system driven by amyloid-beta and tau, aging, and systemic health; single-target drugs have limited impact, so researchers are pushing integrated, multi-pronged therapies—combining approaches like gene editing, senolytics, metabolic interventions, and gut-brain axis strategies—guided by early biomarkers and advanced models to slow, halt, or prevent disease progression.

Midlife Vitamin D Linked to Lower Tau Buildup in Brain
science1 day ago

Midlife Vitamin D Linked to Lower Tau Buildup in Brain

A study of 793 adults found higher vitamin D levels in midlife (around age 39) were associated with fewer tau protein tangles in brain scans about 16 years later; there was no link with amyloid-beta. The results show association, not causation, and researchers say clinical trials are needed to determine if vitamin D supplementation could help reduce dementia risk.

Stronger Flu Vaccine May Shield Seniors From Alzheimer's, Large Study Finds
health2 days ago

Stronger Flu Vaccine May Shield Seniors From Alzheimer's, Large Study Finds

A UTHealth Houston study of nearly 200,000 adults aged 65+ found that recipients of the high-dose influenza vaccine had about a 55% lower risk of developing Alzheimer’s disease compared with those who received the standard dose, with stronger effects in women. The finding builds on earlier work showing roughly a 40% risk reduction from influenza vaccination and suggests vaccine dosage may influence brain health, though access to high-dose vaccines remains uneven.

Alzheimer's death switch found, scientists halt it in mice with FP802
science11 days ago

Alzheimer's death switch found, scientists halt it in mice with FP802

Researchers at Heidelberg University have identified a toxic complex formed by NMDA receptors and TRPM4 in the brain that they describe as a death switch driving neuron death in Alzheimer's disease. In mice, they used FP802, a TwinF Interface Inhibitor, to disrupt this complex, which slowed cognitive decline, preserved dendrites and synapses, and reduced amyloid plaques. The findings suggest a new therapeutic approach that targets the death switch rather than amyloid buildup, but human trials are not yet underway and results are limited to animal studies. Development with FundaMental Pharma is progressing toward potential clinical testing.

Paul Schrader Breaks Silence on Mary Beth Hurt’s Passing in Facebook Post
entertainment11 days ago

Paul Schrader Breaks Silence on Mary Beth Hurt’s Passing in Facebook Post

Mary Beth Hurt, the Tony-nominated actress known for Interiors and The World According to Garp, died in New Jersey after a decade-long battle with Alzheimer's disease. Her husband, filmmaker Paul Schrader, posted his first public comments on Facebook, reflecting on a memory of his father and saying, 'Now I’m in that place,' after years as Hurt’s caregiver and moving to be near her in New York. The couple, married in 1983, collaborated on four Schrader-directed films; their daughter Molly paid tribute to Hurt on Instagram.

Mary Beth Hurt, Esteemed Actress of Interiors, Dies at 79
entertainment12 days ago

Mary Beth Hurt, Esteemed Actress of Interiors, Dies at 79

Renowned actress Mary Beth Hurt, known for Interiors and The World According to Garp, died at 79 from Alzheimer's disease, confirmed by her daughter Molly Schrader and husband Paul Schrader. A Tony-nominated performer with a long stage career, Hurt also collaborated with Schrader on Affliction and Light Sleeper and appeared in notable films including Slaves of New York, The Age of Innocence, and Six Degrees of Separation.

Mary Beth Hurt, Renowned Stage and Screen Actress, Dies at 79
obituaries12 days ago

Mary Beth Hurt, Renowned Stage and Screen Actress, Dies at 79

Mary Beth Hurt, the Tony-nominated actress known for The Age of Innocence and Six Degrees of Separation, died at 79 after an Alzheimer’s diagnosis in 2015; born in 1946 in Iowa, she rose from Off-Broadway to three Tony nominations and appeared in films such as Interiors, The World According to Garp, and Autumn in New York. She was married to William Hurt and later Paul Schrader, leaving daughter Molly Schrader and son Sam.

Speed-Training for the Brain Linked to Lower Dementia Risk Over 20 Years
health13 days ago

Speed-Training for the Brain Linked to Lower Dementia Risk Over 20 Years

NIH-funded follow-up of the ACTIVE trial shows that speed-of-processing cognitive training in adults 65+ reduced dementia risk for up to 20 years, with the greatest benefit when booster sessions were included. About 40% of participants who received boosters developed dementia vs 49% in controls, a 25% lower risk; memory and reasoning trainings did not show the same long-term protection. The training’s adaptive, implicit-learning approach—focusing on rapid visual processing—may underlie the effect and could complement other brain-healthy lifestyle strategies, though more research is needed to understand mechanisms and broader public-health impact.

Blood Test Signals Dementia Risk Decades Before Onset
science13 days ago

Blood Test Signals Dementia Risk Decades Before Onset

UC San Diego researchers identify plasma phosphorylated tau 217 (p-tau217) as a blood biomarker that predicted future dementia risk decades before symptoms, especially in older women and APOE ε4 carriers; its predictive power varies with age and hormone therapy history, suggesting potential for earlier prevention and monitoring, though not yet ready for routine clinical use.

Lifelong Learning May Help Shield the Aging Brain, Study Suggests
health14 days ago

Lifelong Learning May Help Shield the Aging Brain, Study Suggests

A Rush University study linked sustained cognitive engagement across life (reading, learning new things, puzzles, etc.) with a lower risk of Alzheimer's disease (about 38%) and a slower progression of mild cognitive decline (about 36%), suggesting cognitive enrichment builds brain reserve and resilience, though it stops short of proving causation.

Passion Fruit Molecule Promises to Slow Alzheimer’s Progression
science14 days ago

Passion Fruit Molecule Promises to Slow Alzheimer’s Progression

Scientists report that a compound called alpha-amyrin found in passion fruit slowed memory decline in mice with Alzheimer’s-like symptoms and remained in the bloodstream long enough to be a candidate for future medications. The study, published in Advanced Science, suggests this molecule could lead to new therapies, and human data linked higher fruit/vegetable intake with lower brain plaque, though clinical trials are needed to confirm safety and effectiveness.

New Neuronal IDOL Target Could Cut Alzheimer's Plaque Burden
science15 days ago

New Neuronal IDOL Target Could Cut Alzheimer's Plaque Burden

Researchers at Indiana University identified neuronal IDOL as a new drug target for Alzheimer’s, showing that reducing IDOL activity in brain neurons lowers amyloid plaques and APOE levels, while boosting receptors that regulate APOE and amyloid. The neuron-focused approach produced stronger effects than targeting microglia, suggesting a potential multi-benefit therapy. Next steps include preclinical safety testing and evaluating whether IDOL blockade preserves synapses and reduces tau pathology.

Higher unprocessed meat intake linked to slower dementia progression in APOE4 carriers
health15 days ago

Higher unprocessed meat intake linked to slower dementia progression in APOE4 carriers

A Swedish observational study found that adults over 60 with APOE3/4 or APOE4/4 genotypes who consumed more unprocessed meat had slower cognitive decline and a lower risk of dementia, compared with those eating less meat; processed meat was associated with higher risk. The study does not prove causation and intervention studies are needed.