New Developments in MS Research: Clemastine, Retrospective Analysis, and PIPE-791

Researchers have found evidence of myelin repair induced by clemastine based on MRI data from the ReBUILD trial, but it can only be partially effective at the doses currently being used and can have a sedative effect. A retrospective opinion piece discusses the challenges that remain in treating MS despite the gains made in recent decades. The PIPE-791 study, a potential treatment aimed at protecting damaged myelin, has been cleared for a Phase 1 study in healthy volunteers.