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Myelin Repair

All articles tagged with #myelin repair

Two Drugs Spark Remyelination in MS Models, Hinting at Nerve Repair
health14 days ago

Two Drugs Spark Remyelination in MS Models, Hinting at Nerve Repair

Finnish researchers identified two drug molecules that promote remyelination in MS models, suggesting a potential path to repairing nerve damage rather than only reducing inflammation. One drug targets the unfolded protein response in brain cells, while the other alters scar tissue around damaged areas. Both produced strong remyelination and lower neuroinflammation in animal and cell models, but human trials and brain-delivery challenges remain before clinical use.

via SciTechDaily|
#health#multiple-sclerosis#myelin-repair
"Revolutionary Breakthrough: Unleashing the Power of Myelin Regeneration"
neuroscience2 years ago

"Revolutionary Breakthrough: Unleashing the Power of Myelin Regeneration"

Researchers have discovered a new biological mechanism for myelin repair and regeneration, focusing on the Daam2 protein and CK2α kinase. Myelin, crucial for efficient neurotransmission, is often damaged in neurological diseases such as multiple sclerosis and cerebral palsy. The study found that phosphorylation of Daam2 by CK2α negatively regulates Wnt activity during white matter development and injury. This discovery offers potential therapeutic pathways for myelin regeneration and provides hope for treating currently untreatable neurological conditions.

via Neuroscience News|
#ck2a-kinase#daam2-protein#myelin-repair
Estriol and T-cell changes show promise for MS treatment.
health2 years ago

Estriol and T-cell changes show promise for MS treatment.

Estriol, a hormone produced during pregnancy, has been found to reduce disease severity and promote myelin repair in the cortex, a key brain region affected in multiple sclerosis (MS), in a mouse model of the disease. The hormone has been in use for decades as a therapy to help manage symptoms of menopause and has a generally good safety profile. Based on these promising results, the scientists are calling for studies to examine the potential for this hormone as a treatment for women with MS.

via Multiple Sclerosis News Today|
#estriol#health#hormone-therapy
New Developments in MS Research: Clemastine, Retrospective Analysis, and PIPE-791
health2 years ago

New Developments in MS Research: Clemastine, Retrospective Analysis, and PIPE-791

Researchers have found evidence of myelin repair induced by clemastine based on MRI data from the ReBUILD trial, but it can only be partially effective at the doses currently being used and can have a sedative effect. A retrospective opinion piece discusses the challenges that remain in treating MS despite the gains made in recent decades. The PIPE-791 study, a potential treatment aimed at protecting damaged myelin, has been cleared for a Phase 1 study in healthy volunteers.

via Multiple Sclerosis News Today|
#clemastine#clinical-trials#health
Antihistamine Shows Promise in Reversing Multiple Sclerosis.
neuroscience3 years ago

Antihistamine Shows Promise in Reversing Multiple Sclerosis.

A new study has identified the over-the-counter antihistamine, clemastine, as an effective drug for brain repair in Multiple Sclerosis (MS) patients. Using a newly-developed MRI scan technique, scientists were able to observe and measure the impact of clemastine on brain myelin levels. The study offers the first documented example of brain repair for a chronic neurological condition through MRI and is expected to set a standard for future research into myelin-rebuilding therapies. Clemastine is also being considered for use in treating brain injury in premature infants, who often experience myelin damage.

via Neuroscience News|
#brain-injury#clemastine#mri
"MS Patients Benefit from Yoga, Vitamin D, Myelin Repair, and Fall Risk Prevention"
health3 years ago

"MS Patients Benefit from Yoga, Vitamin D, Myelin Repair, and Fall Risk Prevention"

A recent study found that yoga is better than physical therapy at improving the quality of life for MS patients. A high-dose vitamin D supplement did not reduce the risk of relapses in people with relapsing-remitting MS (RRMS) already using a disease-modifying therapy. An investigational oral therapy called PIPE-307 is expected to launch a Phase 2 trial to boost remyelination. A new wearable system called NeurOpTrek powered by Sensoria is designed to reduce the risk of falls and improve balance, gait, and coordination for older patients and people with MS.

via Multiple Sclerosis News Today|
#fall-risk#health#multiple-sclerosis