Women shed more weight than men on GLP-1 drugs like Mounjaro, study finds

A study in Obesity reports that overweight or obese women on tirzepatide (Mounjaro) lost about 15% of body weight after 15 months, compared with ~11% for men. While younger participants (<45) tended to lose more, age wasn’t the strongest predictor. Greater weight loss occurred among those without Type 2 diabetes, who hadn’t used weight‑loss meds before, and at higher doses. Possible explanations include slower drug clearance in women and estrogen’s effects; broader meta-analyses also show women often lose more weight on GLP-1 therapies.