All articles tagged with #weight loss
Jelly Roll guest-hosts Jimmy Kimmel Live for four nights, using his monologue to roast Donald Trump, including weight jokes and a crude line about the president’s anatomy, while noting his own dramatic 300-pound weight loss and a small acting role.
A new experimental compound called TOFA increased energy expenditure by up to 18% in mice without reducing appetite or increasing activity, and it also blocks two enzymes involved in fat and cholesterol production. Unlike GLP-1 drugs (Ozempic/Wegovy/Zepbound), which can cause lean muscle loss during rapid weight loss, TOFA could enable fat loss while preserving muscle and might be used alongside GLP-1 therapies. The findings are early and limited to animals, with human trials not yet underway.
Tammy Slaton, star of TLC’s 1000-lb Sisters, has shed over 500 pounds and appears unrecognizable from the show’s early days as season nine approaches. A teaser shows her engagement to girlfriend Andrea Dalton and her ongoing efforts to repair her relationship with sister Amy Slaton, while Amy’s own weight-loss journey continues; season nine premieres September 1 on TLC.
Benny Blanco posted a TikTok documenting a five-day diet of only Domino’s large thin-crust pizza, starting at 152.2 pounds and ending at 147.5 pounds (a 4.7-pound loss), with clips including time on a date with wife Selena Gomez who appears in the video.
John Goodman, the 74-year-old actor known for Roseanne and films like The Big Lebowski, has reportedly shed about 90kg, a transformation that has been unfolding publicly for years and recently drew renewed attention after a photo shared by fellow actor David DeLuise.
GLP-1 weight-loss medications shrink more than waists: users report big savings on groceries and takeout as cravings decline, but insurance coverage and dosing introduce new costs, producing mixed budget outcomes—from thousands saved on food to hundreds more spent on medications, wardrobe, and lifestyle changes.
Enveda’s ENV-308 is an experimental daily pill designed to mimic some effects of exercise by delivering Lac-Phe to suppress appetite. In a Phase 1 trial with 88 healthy adults, the drug was safe and well tolerated across dose levels, with an “exceptional” gastrointestinal safety profile. Lac-Phe is a natural compound formed when lactate and phenylalanine combine during exercise and can reduce hunger, but it degrades quickly; ENV-308 aims to prolong these effects and potentially complement GLP-1 weight-loss drugs. Animal studies suggest it may preserve lean muscle during weight loss. Next steps include trials to test actual weight and metabolic outcomes and interactions with other therapies. Even if successful, it will take years and FDA approval before it could reach patients, and it won’t replace the benefits of physical activity.
A UNC study comparing Med-South (a Southern-adapted Mediterranean diet) with Weight Watchers found both programs produced similar weight loss over two years, but Med-South improved diet quality and sustainability by emphasizing whole foods and behavioral changes guided by dietitians rather than strict point tracking.
Oral Wegovy (a GLP-1 weight‑loss pill) must be taken on an empty stomach with plain water, not with coffee or other beverages that can affect absorption. The FDA label requires a 30‑minute fasting window after taking the tablet before eating, drinking other beverages, or taking other meds. A typical morning routine is take Wegovy with water, wait 30 minutes, then eat and drink separately. GLP-1 medications can slow stomach emptying, so avoid mixing with other oral medicines and consult a clinician for personal guidance.
GLP-1 weight-loss drugs show benefits beyond shedding pounds, including reduced inflammation, potential arthritis relief, and cardiovascular improvements, and may even curb alcohol cravings. However, they carry risks such as vitamin deficiencies, loss of eating enjoyment (hedonia), reduced appetite for food, and muscle/bone loss during weight loss, especially in frail patients. Off-label use in people who are not overweight poses safety concerns. A new triple-agonist drug, retatrutide, may deliver 25–30% weight loss—similar to bariatric surgery—but brings more side effects and is in Phase 3 trials, with potential approval in the coming years. Long-term success depends on continued use with diet/exercise; stopping reverses effects and weight tends to rebound.
Christopher Schwarzenegger, 28, Arnold and Maria Shriver’s son, has revealed a dramatic transformation after reportedly shedding some 30 pounds and building muscle. The rare glimpse came from sister Katherine during a Cape Cod family vacation, where she shared a beachside Instagram photo showing his slimmer, toned frame, with Patrick Schwarzenegger also in the group.
Netflix has greenlit Weight To Date from The Intellectual Property Corporation (IPC), marking the first sale by IPC founders Eli Holzman and Aaron Saidman since they left Sony Pictures Television. The non-scripted, docu-format series will follow about 10–12 singles who’ve lost a dramatic amount of weight as they explore dating, identity and love, drawing comparisons to Indian Matchmaking and Love on the Spectrum. Jeanne Begley also executive produces as Netflix expands its unscripted slate.
In a 16-week randomized trial, adults with overweight following an ad libitum low-fat vegan diet ate roughly the same amount of food by weight but consumed about 357 fewer calories per day and reduced dietary energy density by ~30%, leading to weight loss without calorie counting or portion control.
GLP-1 weight‑loss drugs are reshaping fitness priorities: Life Time’s survey finds 42.3% name getting physically stronger as their top health goal and 82% plan to focus on overall health, signaling a shift from aesthetics to longevity and daily function. Experts say strength training preserves lean muscle, bone health, and mobility as we age, making it foundational for independence. Trends emphasize consistent 2–4 weekly strength sessions plus mobility work, sleep and recovery, and the use of wearables/AI to track progress. The goal is sustainable, functional fitness that lasts a lifetime.
Chrissy Metz defends herself against ongoing weight-related criticism, explains she began GLP-1 medication after her father's death, says the meds quiet the 'food noise', and mentions a Ro telehealth partnership while continuing in the Broadway show & Juliet.