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Glp 1

All articles tagged with #glp 1

Ozempic Shows Promise for Mood Stability in Bipolar Disorder
health3 hours ago

Ozempic Shows Promise for Mood Stability in Bipolar Disorder

Australian researchers analyzed 15,000 people over 15 years and found that semaglutide (Ozempic) lowered the risk of psychiatric hospitalization in bipolar disorder by about 21%, a benefit not seen with related GLP-1 drugs. The findings suggest GLP-1 signaling may protect the brain by reducing inflammation and cellular stress, potentially improving mood stability, though more research is needed to confirm direct effects on bipolar symptoms.

via New York Post|
#bipolar-disorder#glp-1#health
GLP-1 Drugs Prove Broad Health Benefits
health16 hours ago

GLP-1 Drugs Prove Broad Health Benefits

GLP-1 drugs, used for diabetes and obesity, show potential beyond weight loss—lowering cardiovascular risk, easing sleep apnea, supporting kidney and liver health, and possibly reducing cancer risk and addiction. Experts urge cautious optimism; evidence for healthy individuals or longevity is preliminary, and safety monitoring remains important. These drugs are widely used, with ongoing research into broader uses and dosing.

via TODAY.com|
#cancer#diabetes#glp-1
TOFA signals fat-burning in mice without muscle loss, hinting at a GLP-1 combo therapy
health1 day ago

TOFA signals fat-burning in mice without muscle loss, hinting at a GLP-1 combo therapy

A new experimental compound called TOFA increased energy expenditure by up to 18% in mice without reducing appetite or increasing activity, and it also blocks two enzymes involved in fat and cholesterol production. Unlike GLP-1 drugs (Ozempic/Wegovy/Zepbound), which can cause lean muscle loss during rapid weight loss, TOFA could enable fat loss while preserving muscle and might be used alongside GLP-1 therapies. The findings are early and limited to animals, with human trials not yet underway.

via Currently.com|
#glp-1#health#muscle-mass
Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice
health-and-medicine3 days ago

Old ACC inhibitor TOFA drives fat burning while preserving muscle in mice

UC Berkeley researchers report that TOFA, an old ACC inhibitor, lowers lipid production and activates fat-burning energy pathways in obese mice, increasing energy use by up to 18% and reducing fat while preserving lean mass; it also improves insulin sensitivity and triglycerides and works additively with GLP-1 obesity drugs, though safety in humans remains untested and researchers are pursuing clinical development.

via Science Daily|
#energy-expenditure#glp-1#health-and-medicine
health-policy3 days ago

Most states pass on Trump’s discounted GLP-1 deal, tightening Medicaid access

Trump’s plan to negotiate discounted GLP-1 weight‑loss drugs for Medicaid has stalled: only Indiana has signed on, while 29 states will not participate due to tight budgets. Twelve states still cover GLP-1s, but five of those recently ended coverage (California, Massachusetts, New Hampshire, Pennsylvania and South Carolina), with Rhode Island set to end in October. As other states weigh participation, many cite cost concerns and the risk to budget sustainability, meaning access to these drugs for low-income Americans on Medicaid is shrinking even as some argue these medications could reduce long-term health costs.

via Politico|
#drug-pricing#glp-1#health-policy
Experimental Pill Tries to Turn Exercise Into a Daily Tablet
health5 days ago

Experimental Pill Tries to Turn Exercise Into a Daily Tablet

Enveda’s ENV-308 is an experimental daily pill designed to mimic some effects of exercise by delivering Lac-Phe to suppress appetite. In a Phase 1 trial with 88 healthy adults, the drug was safe and well tolerated across dose levels, with an “exceptional” gastrointestinal safety profile. Lac-Phe is a natural compound formed when lactate and phenylalanine combine during exercise and can reduce hunger, but it degrades quickly; ENV-308 aims to prolong these effects and potentially complement GLP-1 weight-loss drugs. Animal studies suggest it may preserve lean muscle during weight loss. Next steps include trials to test actual weight and metabolic outcomes and interactions with other therapies. Even if successful, it will take years and FDA approval before it could reach patients, and it won’t replace the benefits of physical activity.

via New York Post|
#env-308#exercise-pill#glp-1
Morning coffee may blunt Wegovy absorption, doctors warn
health6 days ago

Morning coffee may blunt Wegovy absorption, doctors warn

Oral Wegovy (a GLP-1 weight‑loss pill) must be taken on an empty stomach with plain water, not with coffee or other beverages that can affect absorption. The FDA label requires a 30‑minute fasting window after taking the tablet before eating, drinking other beverages, or taking other meds. A typical morning routine is take Wegovy with water, wait 30 minutes, then eat and drink separately. GLP-1 medications can slow stomach emptying, so avoid mixing with other oral medicines and consult a clinician for personal guidance.

via New York Post|
#absorption#coffee#glp-1
Tirzepatide Might Trigger More Hair Loss Than Semaglutide, Early Study Suggests
health7 days ago

Tirzepatide Might Trigger More Hair Loss Than Semaglutide, Early Study Suggests

A preprint study comparing tirzepatide (Zepbound/Mounjaro) with semaglutide (Ozempic/Wegovy) in 8,985 women found higher incident alopecia with tirzepatide (5.44% vs 3.63%). At six months, 1.55% vs 1.24%; at twelve months, 4.20% vs 2.88%. After adjusting for weight loss, hair loss remained more common with tirzepatide (4.24% vs 3.33%), suggesting weight loss alone doesn’t explain the difference. The study is observational and not yet peer‑reviewed. Experts note GLP-1 meds can cause temporary shedding, and persistent patches should be evaluated by a dermatologist; patients should not stop their medication without physician guidance. The differing receptor targets (GIP/GLP-1 for tirzepatide vs GLP-1 alone for semaglutide) may influence the hair follicle environment, but mechanisms are not yet clear.

via Women's Health|
#alopecia#glp-1#hair-loss
GLP-1 Drugs for Kids Divide Parents and Doctors
health7 days ago

GLP-1 Drugs for Kids Divide Parents and Doctors

A growing number of families are turning to pediatric GLP-1 therapies such as Wegovy and Zepbound to treat obesity and related health problems in children, hoping to jump‑start healthier habits and prevent long‑term disease. While clinicians say there can be real medical benefits beyond weight loss, experts caution about unknown long‑term effects on development, potential puberty impacts, access barriers, and social stigma; use remains relatively rare but is expanding in pediatric care.

via New York Post|
#glp-1#health#obesity
Parents on GLP-1s push for open talks with kids about food and body image
health8 days ago

Parents on GLP-1s push for open talks with kids about food and body image

CNN reports that about half of parents taking GLP-1 weight-loss medications are already discussing the treatment with their children. Experts warn that secrecy or overly restrictive dieting talk can harm kids’ body image and risk eating disorders, so the piece advocates neutral, health-focused conversations, modeling balanced eating, and keeping health separate from weight. It also underscores kids’ ongoing caloric needs, offers practical tips for shared meals and responding to compliments on weight loss, and points to resources for eating-disorder support.

via CNN|
#body-image#glp-1#health
GLP-1s reshape parenting talk: guiding kids on food and body image
health9 days ago

GLP-1s reshape parenting talk: guiding kids on food and body image

CNN reports that about half of parents using GLP-1 medications are talking openly with their children about their use; experts warn that secrecy or shaming can fuel eating disorders. The piece urges neutral, health-focused conversations, modeling balanced eating and regular meals, and framing health beyond weight. It also emphasizes that kids need ample calories for growth and advises avoiding dieting talk around children while offering support if eating disorders arise.

via CNN|
#body-image#glp-1#health