US switch to recombinant shingles vaccine linked to lower cardiovascular risk

A Nature Medicine study using US electronic health record data finds that older adults vaccinated predominantly with the recombinant shingles vaccine exhibit a lower cardiovascular disease burden over seven years, with reduced risks for heart failure and ischemic heart disease, and a modest, sex-specific reduction in ischemic stroke; though associations persist across analyses, causality cannot be established and effects may wane over time.