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Ultra-low PSA target linked to better survival in metastatic prostate cancer
16 days ago•Source: News-Medical
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10.645 min•22 days ago
New combo strategy sharpens antibody-drug conjugates against advanced prostate cancer
UCLA researchers report that pairing DNA-damaging antibody-drug conjugates (ADCs) with BCL-XL inhibitors boosts cancer cell death and slows tumor growth in metastatic castration-resistant prostate cancer, shown in lab and mouse models. The work highlights co-targeting proteins B7-H3, PSMA, and STEAP1 to reach more cancer cells and notes that tumors with intact TP53 respond best, suggesting genetic testing could guide patient selection. The study provides a framework for next-generation, multi-payload, multi-target ADCs to improve durability of prostate cancer therapies, pending clinical trials.
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Tailored DNA vaccine sparks immune response against glioblastoma in early trial
A phase 1 trial at Siteman Cancer Center shows a personalized neoantigen DNA vaccine (GNOS-PV01) for glioblastoma is safe and elicits robust immune responses; among nine patients, about two-thirds had no progression at six months and two-thirds were alive at one year, including a long-term recurrence-free survivor, indicating potential benefit and the need for larger trials.
External artificial lung buys time for life-saving transplant
A 33-year-old man with influenza-triggered ARDS survived 48 hours on an external artificial-lung system that maintained blood flow to the heart, allowing a double lung transplant. He recovered rapidly, kidneys and heart function normalized, and years later shows no rejection, suggesting the device could help other critically ill patients awaiting transplants.
Gut Microbes and Auto-Brewery Syndrome: Understanding Self-Produced Alcohol
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Bioinformatics Accelerates Development of Regenerative Therapies for Spinal Cord Injury
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Implant-Based Slow Release of Molecules to Prevent Glioblastoma Recurrence
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Mapping Tumor Immune Niches in Diffuse Large B Cell Lymphoma
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Host-Directed Adjuvant Boosts Antibiotic Effectiveness Against Bacterial Persisters
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Scientists Develop Drug to Counteract Cancer-Related Wasting
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Scientists Achieve First Human Transplant Using Enzyme-Converted Universal Donor Kidney
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Innovative Methods Unveil Cancer Evolution and Resistance in Ovarian Cancer
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