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Observational Study

All articles tagged with #observational study

health1 month ago•7 min saved

Regular Cialis Use Linked to Modest Glaucoma Risk, Study Finds

An observational study of 36,927 men aged 40+ found that regular tadalafil use over five years was associated with a higher glaucoma diagnosis rate (3.93% vs 3.16% in non-users), a 22% relative increase with an absolute difference of about 0.77 percentage points. The study cannot prove causation, and researchers note that the overall risk remains small; patients using tadalafil long-term should discuss eye monitoring with a clinician rather than stopping the medication.

via ScienceAlert|

#eye-health #glaucoma #health

health1 month ago•62 min saved

Weight regain after obesity medications linked to higher suicide-risk signals, study finds

In a South Korean observational study of 27,741 adults, those who used prescription weight‑loss meds in the past year were more likely to report depression (1.9x), mental‑health counseling (2x), suicidal thoughts (2.7x), and suicide attempts (1.7x) than non-users; the risk was highest among those who gained or regained weight (about 4.2x for suicidal ideation). The authors caution that the study cannot prove causation and that obesity or weight‑loss challenges may contribute; more research is needed to understand risks across different weight‑loss drugs.

via Yahoo|

#health #observational-study #south-korea

health1 month ago•6 min saved

Xylitol in the blood linked to higher cardiovascular risk in large population study

An observational analysis using the CLSA and EPIC-Norfolk cohorts found that higher blood levels of xylitol are linked to a greater risk of major adverse cardiovascular events (heart attack, stroke, or death) in the general population, with a 57% higher risk over 6 years in CLSA and 18% higher over 30 years in EPIC-Norfolk, showing a dose-dependent pattern. The study does not establish causality and researchers urge further investigation, while experts advise moderating artificial sweeteners and favoring natural sweeteners when possible.

via Medical News Today|

#artificial-sweeteners #cardiovascular-risk #esc-congress-2026

health1 month ago•6 min saved

Early statin use after type 2 diabetes linked to lower dementia risk in large Danish study

A large Danish observational study of 132,585 adults with type 2 diabetes found starting a statin within one year of diagnosis was linked to a 15% reduction in dementia risk over 10 years, with a 10% reduction if started after 1–5 years; authors emphasize association, not causation, and note the benefit was mainly in vascular dementia, underscoring statins as part of broader diabetes care; more trials needed to prove causality.

via Fox News|

#dementia #diabetes #health

health1 month ago•7 min saved

Early hormone therapy linked to lower dementia risk, study finds

A UK Biobank analysis of 183,450 postmenopausal women (average age ~60) found that hormone replacement therapy started between ages 46 and 56 was linked to about a 10% lower risk of all-cause dementia and a 16% lower risk of Alzheimer's over 13 years; starting after 56 showed no dementia benefit. As an observational study, it cannot prove causation, and researchers emphasize individualized risk‑benefit decisions and the need for randomized trials to confirm findings, noting potential therapy risks and that results may not generalize to all populations.

via Fox News|

#alzheimers-disease #dementia #health

medicine1 month ago•38 min saved

Recombinant Shingles Vaccine Linked to Lower Cardiovascular Burden in a Large Natural Experiment

A national, quasi-experimental analysis comparing adults ≥60 who were vaccinated before vs after the switch from live to recombinant shingles vaccine found the recombinant vaccine associated with about a 9% reduction in a seven-year composite cardiovascular endpoint (ischemic heart disease, heart failure, stroke). Benefit was strongest for ischemic heart disease and heart failure, with some sex-specific effects, and persisted across sensitivity analyses. The authors call for clinical trials to investigate potential cardioprotective mechanisms of shingles vaccines.

via Nature|

#cardiovascular-disease #medicine #natural-experiment

health1 month ago•3 min saved

Early statin use linked to lower dementia risk in large Danish study

A 15-year Danish observational study of 132,585 individuals with type 2 diabetes found that starting statins was associated with a 15% lower dementia risk over 10 years when begun early (versus 10% if started later); while not proving causation, the findings—presented at the European Society of Cardiology congress and published in Lancet Regional Health Europe—support the idea that lowering LDL cholesterol and improving vascular health from midlife could help prevent or delay dementia.

via The Guardian|

#cardiovascular-health #dementia #health

health-and-medicine1 month ago•10 min saved

Chronic Melatonin Use Linked to Elevated Heart Failure Risk

A large, observational study using de-identified health records found that adults with chronic insomnia who used melatonin for at least 12 months had about a 90% higher five-year risk of developing heart failure (4.6% vs 2.7%), plus higher rates of heart-failure-related hospitalization (19.0% vs 6.6%) and all-cause death (7.8% vs 4.3%). The results do not prove causation and could be influenced by unmeasured factors or misclassification of OTC melatonin use; researchers call for more research and cautious discussion of long-term melatonin use with patients.

via Science Daily|

#cardiovascular-risk #health-and-medicine #heart-failure

medical-research1 month ago•12 min saved

US switch to recombinant shingles vaccine linked to lower cardiovascular risk

A Nature Medicine study using US electronic health record data finds that older adults vaccinated predominantly with the recombinant shingles vaccine exhibit a lower cardiovascular disease burden over seven years, with reduced risks for heart failure and ischemic heart disease, and a modest, sex-specific reduction in ischemic stroke; though associations persist across analyses, causality cannot be established and effects may wane over time.

via News-Medical|

#cardiovascular-disease #medical-research #nature-medicine

health1 month ago•81 min saved

High-Dose Vitamin D Linked to 4-Point Boost on Brain Test in Early Cognitive Decline

A small observational study of 54 adults with mild cognitive impairment and sleep disturbances found that those taking 5,000+ IU of vitamin D daily scored about four points higher on cognitive testing (Montreal Cognitive Assessment) than peers not taking the supplement; lower doses showed only nominal gains and results were not always statistically significant. The finding held regardless of vitamin D form (D2 or D3). Researchers caution that this shows association, not causation, and call for clinical trials to determine whether vitamin D supplementation can meaningfully improve cognition in people with early cognitive changes. The Mayo Clinic notes a typical recommended daily intake of 600–800 IU (under age 70) and an upper limit of 4,000 IU.

via inc.com|

#brain-health #cognitive-decline #health

health1 month ago•6 min saved

Shingrix linked to lower dementia risk in older adults, study suggests

A Brown University study of more than 509,000 adults aged 66+ found that those who had at least one Shingrix dose showed a 24% relative reduction in dementia diagnoses over four years versus unvaccinated peers, based on electronic health records and Medicare data; researchers stress this is an association, not proof of causation, and the vaccine’s primary purpose is shingles prevention, though explanations include fewer shingles-related complications and potential vascular benefits. The study was funded by GSK.

via Fox News|

#dementia-risk #health #observational-study

science1 month ago•22 min saved

Shingrix Could Protect the Heart for Years, Study Suggests

A US study of about 70,000 adults aged 60+ found that the recombinant shingles vaccine Shingrix is associated with a lower risk of cardiovascular disease years after vaccination compared with the older live vaccine, with the strongest effect on ischemic heart disease and heart failure; the finding hints at immune-system changes beyond shingles, though the observational design aims to reduce bias by comparing groups who chose vaccination rather than vaccinated versus unvaccinated.

via ZME Science|

#cardiovascular-disease #immune-system #observational-study

health1 month ago•6 min saved

First and Last Meal Timing Tied to Longevity in Large Study

In a large US study of 31,044 adults followed for about 8.6 years, later first-meal timing (especially after noon) and later last meals were linked to higher all-cause and cardiovascular mortality, with the lowest risk around an 8 pm last meal; however, the findings are observational and could reflect underlying health, routines, or other factors, so they do not prove that changing meal times will extend life.

via ScienceAlert|

#circadian-rhythm #health #meal-timing

health1 month ago•3 min saved

Sugary drinks daily linked to almost triple stomach cancer risk, study shows

Researchers analyzing data from more than 100,000 participants in two long-running cohorts found that consuming at least one sugary drink daily was linked to nearly a threefold increase in gastric (stomach) cancer risk, while artificially sweetened beverages showed no such association. The study, which adjusts for other risk factors, shows an association—not causation—and the mostly white healthcare-professional sample limits generalizability; further research is needed to confirm findings in diverse populations and to clarify the role of fructose.

via LiveNOW from FOX|

#fructose #health #helicobacter-pylori

health2 months ago•55 min saved

Wine Linked to Lower Death Risk in Large UK Study

In data from more than 340,000 UK Biobank participants (2006–2022), wine at low to moderate levels was associated with lower all-cause and cardiovascular mortality, while beer and spirits were linked to higher death risk. High overall alcohol consumption raised all-cause mortality by 24%, and the type of beverage mattered for lower risk. The authors note that this is observational and may reflect healthier lifestyles among wine drinkers, so causality cannot be established; randomized trials are needed for confirmation.

via Yahoo|

#alcohol-consumption #cardiovascular-death #health