Astrocytes Remote from Lesions Regulate Microglia in White Matter Repair
TL;DR
The study reveals that lesion-remote astrocytes (LRAs) in the injured spinal cord adopt distinct molecular states that regulate microglia-mediated white matter repair, primarily through CCN1 secretion, which influences microglial lipid metabolism, debris clearance, and neurological recovery. Loss of astrocyte-derived CCN1 impairs debris clearance and functional recovery, positioning LRAs as key orchestrators in CNS repair processes.
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