Epigenetic Techniques to Control Memory Activation in Neurons
TL;DR
This study developed cell-type- and locus-specific epigenetic editing tools using CRISPR-dCas9 to modulate memory expression in engram cells, demonstrating that targeted epigenetic modifications at the Arc gene locus can bidirectionally regulate memory formation and retention in mice, with effects that are reversible and applicable beyond initial memory consolidation.
Topics:healthneuroscience#crispr-dcas9#engram-cells#epigenetic-editing#memory-formation#memory-regulation#neuroscience
- Cell-type- and locus-specific epigenetic editing of memory expression Nature
- Changing the 'packaging' of DNA in neurons can turn memories on or off in mice Medical Xpress
- Turning Memory On and Off via Epigenetics Technology Networks
- Epigenetic Switch to Turn Memories On and Off Created Neuroscience News
- Unlocking the epigenetic secrets of memory Nature
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