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Epigenetic Editing

All articles tagged with #epigenetic editing

Epigenetic editing goes from concept to clinic in biotech startups
technology1 month ago

Epigenetic editing goes from concept to clinic in biotech startups

A new wave of biotech startups is pursuing targeted epigenetic editing—modifying DNA-associated chemical markers to turn genes on or off—aiming to treat diseases from muscular dystrophy to hepatitis B; companies like Epicrispr and nChroma are leading with dead-Cas9/Cas12F tools and refined methyltransferases, reporting preclinical success and early human dosing, while researchers caution that long‑term safety and off‑target effects remain critical as this approach moves toward the clinic.

via Nature|
#biotechnology-startups#crispr#epigenetic-editing
CRISPR breakthrough activates genes without DNA cuts
science7 months ago

CRISPR breakthrough activates genes without DNA cuts

Scientists at UNSW Sydney have developed a new CRISPR-based epigenetic editing technique that can turn genes on without cutting DNA, by removing chemical methyl groups that silence genes. This approach could lead to safer gene therapies for conditions like Sickle Cell disease, as it avoids the risks associated with DNA strand breaks. The research demonstrates that methylation directly controls gene activity and opens new possibilities for treating genetic disorders by reactivating silenced genes.

via ScienceDaily|
#crispr#dna-methylation#epigenetic-editing
CRISPR Innovation Promises New Era in Genetic Disease Therapy
science7 months ago

CRISPR Innovation Promises New Era in Genetic Disease Therapy

Researchers at UNSW Sydney have developed a safer CRISPR-based epigenetic editing technique that can switch genes on and off without cutting DNA, offering promising new treatments for genetic diseases like Sickle Cell by reactivating silenced genes through removal of methyl groups, potentially reducing risks associated with traditional gene editing.

via SciTechDaily|
#crispr#dna-methylation#epigenetic-editing
Epigenetic Techniques to Control Memory Activation in Neurons
neuroscience10 months ago

Epigenetic Techniques to Control Memory Activation in Neurons

This study developed cell-type- and locus-specific epigenetic editing tools using CRISPR-dCas9 to modulate memory expression in engram cells, demonstrating that targeted epigenetic modifications at the Arc gene locus can bidirectionally regulate memory formation and retention in mice, with effects that are reversible and applicable beyond initial memory consolidation.

via Nature|
#crispr-dcas9#engram-cells#epigenetic-editing
Scientists Create Fertile Mice with Two Fathers, Revealing New Insights into Mammalian Reproduction
science1 year ago

Scientists Create Fertile Mice with Two Fathers, Revealing New Insights into Mammalian Reproduction

Researchers at Shanghai Jiao Tong University successfully created fertile adult mice from embryos with only paternal DNA by precisely editing imprinting control regions using CRISPR, revealing that genomic imprinting is a key barrier to uniparental mammalian development and opening new avenues in reproductive biology.

via Phys.org|
#androgenetic-mice#crispr#epigenetic-editing