Genetic Alteration in Autism Gene Impacts Hippocampal Cell Identity

A gene called KDM5A, previously linked to autism spectrum disorder (ASD), appears to play a crucial role in determining cell identity in the hippocampus, according to a study by researchers at UT Southwestern Medical Center. Using a mouse model, the researchers found that the loss of KDM5A led to distinct differences in subtypes of excitatory and inhibitory neurons in the hippocampus, suggesting its importance in cell development. The findings provide a mechanistic understanding of ASD and could potentially lead to new therapies for the disorder.