Revolutionary Peptide Restores Memory and Mood in Alzheimer's Patients.

Scientists have found that stimulating the Supramammilary nucleus in the hypothalamus can enhance adult-born neurons in the hippocampus of mouse models of Alzheimer’s disease, restoring both cognitive impairments and mood-related disorders associated with Alzheimer’s in the mice. The study suggests that enhancing adult hippocampus neurogenesis (AHN) could be a way to help Alzheimer’s patients achieve symptom relief. The researchers used optogenetics and chemogenetics to enhance adult-born neurons in the Alzheimer’s brains of mice, and found that multi-level enhancement of ABNs is required to achieve their therapeutic benefits in AD brains.