AI Sifts Reddit for Hidden GLP-1 Drug Side Effects

An AI-assisted analysis of over 410,000 Reddit posts from six years looked for mentions of GLP-1 drugs (semaglutide or tirzepatide). The researchers found signals suggesting potential side effects in reproductive health (e.g., irregular menstrual cycles) and temperature regulation (chills/hot flashes). They emphasize these are not proven effects or a replacement for clinical trials, but suggest online discussions can reveal underreported symptoms worth investigating as GLP-1 therapies become mainstream. Using OpenAI GPT models to scan Reddit enabled rapid signal detection, with findings published in Nature Health.