Brain resilience switch: CgA protein shields against Alzheimer's symptoms in mice
TL;DR
UCSD researchers identify chromogranin A (CgA) as a key driver linking amyloid-beta/tau pathology to cognitive decline: mice lacking CgA still develop Alzheimer’s brain changes but remain cognitively sharp, revealing innate resilience mechanisms and a potential preventive target, though human confirmation and safety considerations are needed, and some authors have industry ties.
Topics:healthscience#alzheimers-disease#asymptomatic-alzheimers#chromogranin-a#cognitive-resilience#mouse-model#science
- Scientists Discover a Key Difference in Brains That Resist Alzheimer's ScienceAlert
- Not all Alzheimer's leads to dementia: The mystery of cognitive resilience Medical Xpress
- AI Cracks the Code on Alzheimer’s Greatest Mystery Yahoo
- UC San Diego researchers work on way to prevent Alzheimer’s disease with molecular ‘switch’ Chicago Tribune
- FINGERS-7B built to eradicate Alzheimer's symptoms News-Medical
Want the full story? Read the original reporting
Read on ScienceAlert