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Mouse Model

All articles tagged with #mouse model

Virus Exposure Triggers Parkinson's-Like Brain Damage in Mice, Study Finds
science2 days ago

Virus Exposure Triggers Parkinson's-Like Brain Damage in Mice, Study Finds

A Texas A&M study used Theiler's murine encephalomyelitis virus (TMEV) in mice to model Parkinson's-like neurodegeneration. The virus infected dopamine-producing neurons and caused motor deficits that persisted after the virus was cleared, suggesting viruses could contribute to Parkinson's risk alongside genetic or environmental factors. This new viral model offers a tool to study disease progression and etiology, complementing genetic or toxin-based models, though TMEV itself does not infect humans.

via ScienceAlert|
#dopaminergic-neurons#mouse-model#neurodegeneration
Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer
health-and-medicine3 days ago

Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer

Researchers engineered ultrasmall silica nanoparticles (Cornell Prime dots) that target prostate tumors, trigger ferroptosis (iron-driven cell death), and remodel the tumor immune environment to a more active state. In mouse models of aggressive prostate cancer, these particles alone modestly improved survival, but when combined with immune checkpoint therapy they produced complete or near-complete remissions and indefinite survival in 4 of 10 mice, rising to 5 of 10 with an added CSF-1R blockade. The treatment localized to tumors with no observed toxicity in healthy tissues. If safety and efficacy translate to humans, this approach could move toward clinical trials as a multi-pronged cancer therapy that enhances immunotherapy effectiveness.

via ScienceDaily|
#ferroptosis#health-and-medicine#immunotherapy
Copper drug reboots brain cleanup pumps to cut Alzheimer's proteins in mice
science20 days ago

Copper drug reboots brain cleanup pumps to cut Alzheimer's proteins in mice

A copper-containing drug Cu(ATSM) boosted brain P-glycoprotein pumps, increased clearance of amyloid-beta by about 42%, and improved spatial memory by about 44% over 56 days in Alzheimer's-model mice, suggesting a potential preclinical approach to restore brain waste clearance, though human trials and safety assessments remain essential.

via ScienceAlert|
#alzheimers-disease#amyloid-beta#cuatsm
Glucosamine may accelerate dementia progression, study finds
health26 days ago

Glucosamine may accelerate dementia progression, study finds

New research links glucosamine, a common osteoarthritis supplement, to faster dementia progression. In mice, glucosamine increased brain glycan production and worsened memory; in humans, ADRD patients who used glucosamine had about a 25% higher mortality risk over about 5 years, while those with milder cognitive impairment showed no mortality increase. Researchers caution that findings are not proof of causation and call for more studies before changing supplement guidance.

via Medical News Today|
#alzheimers-disease#dementia#glucosamine
Brain resilience switch: CgA protein shields against Alzheimer's symptoms in mice
science2 months ago

Brain resilience switch: CgA protein shields against Alzheimer's symptoms in mice

UCSD researchers identify chromogranin A (CgA) as a key driver linking amyloid-beta/tau pathology to cognitive decline: mice lacking CgA still develop Alzheimer’s brain changes but remain cognitively sharp, revealing innate resilience mechanisms and a potential preventive target, though human confirmation and safety considerations are needed, and some authors have industry ties.

via ScienceAlert|
#alzheimers-disease#asymptomatic-alzheimers#chromogranin-a
Gut bacteria hitch a ride to the brain via the vagus nerve, mouse study suggests
science3 months ago

Gut bacteria hitch a ride to the brain via the vagus nerve, mouse study suggests

Emory researchers in mouse models of leaky gut and disease show very small numbers of live gut bacteria can reach the brain, with evidence that the vagus nerve serves as the main route; blocking the nerve reduced brain bacterial presence, suggesting a gut-to-brain transmission axis influenced by diet and genetics and potentially reversible by restoring gut integrity. The findings, published in PLOS Biology, are not yet known to occur in humans and the bacteria were present in very low amounts, leaving open questions about their role in inflammation or disease and whether future gut-targeted therapies could affect brain conditions.

via ScienceAlert|
#gut-brain-axis#microbiome#mouse-model
Cloaked mitochondria extend survival in mouse model of mitochondrial disease
science3 months ago

Cloaked mitochondria extend survival in mouse model of mitochondrial disease

Researchers wrapped mitochondria in red blood cell membranes to shield them from destruction and facilitate cellular entry. In a Leigh syndrome mouse model, this capsule-like delivery increased survival by about two weeks (roughly 20%), with ~80% of cells taking up the mitochondria—significantly higher than naked mitochondria. The approach preserves the mitochondria’s membrane potential, marking a major efficiency advance, though some scientists caution that claims such as preventing Parkinson’s disease in mice may be overstated.

via Nature|
#cell-therapy#leigh-syndrome#mitochondrial-transplantation
Mild COVID-19 May Leave Lasting Brain Changes, Tulane Study Finds
health4 months ago

Mild COVID-19 May Leave Lasting Brain Changes, Tulane Study Finds

A Tulane study using a mouse model found that while both COVID-19 and influenza can cause lasting lung injury, only SARS-CoV-2 infection led to persistent brain inflammation and microvascular damage after the virus was no longer detectable, helping explain long-COVID brain symptoms and highlighting distinct brain-attack mechanisms from flu; findings could inform post-infection monitoring and treatment.

via SciTechDaily|
#brain-inflammation#health#influenza
Mice study hints at nasal vaccine for universal respiratory protection
science4 months ago

Mice study hints at nasal vaccine for universal respiratory protection

Stanford Medicine researchers report an intranasal vaccine that activates innate and adaptive immunity to provide months-long protection in mice against a broad spectrum of respiratory threats—SARS-CoV-2 and other coronaviruses, Staphylococcus aureus, Acinetobacter baumannii, and house dust mite allergen—suggesting a path toward a universal respiratory vaccine, with human safety trials planned next.

via Stanford Medicine|
#innate-immunity#intranasal-vaccine#mouse-model