Chronic Xanthan Gum Exposure Linked to Rat Gut Inflammation

A UNIFESP study in rats shows ten weeks of xanthan gum intake triggers colon inflammation, alters gut microbiota toward dysbiosis, and weakens the intestinal barrier by upregulating Claudin-2. The findings raise concerns about daily consumption of this common thickener in ultra-processed foods and dysphagia products, though occasional use may be safe. The authors call for human translational research, gut-health monitoring, and probiotic strategies, noting historical links to infant necrotizing enterocolitis and regulatory caution.