All articles tagged with #gut microbiota
A 54-participant, double-blind study found that a 13 g daily blend of dietary fibers from resistant dextrin, pectins, citrus fiber, and oat fiber improved spontaneous bowel movements and stool form versus placebo over 28 days in adults with functional constipation, with good tolerability; results suggest combined fibers may offer rapid relief, though larger, multicenter trials are needed.
A Cell Press Blue study finds romantic partners share mouth bacteria far more than gut bacteria, likely due to kissing, and shows mouth bacteria can seed the gut. Analyzing 1,644 saliva–stool samples from 808 people in 207 households, researchers describe a two-step transmission: bacteria spread between cohabitants, then move from mouth to gut, with some gut strains linked to poorer cardiometabolic health, though causality isn’t established; results are correlational and limited by sequencing data.
A new review says berberine isn’t a universal metabolic fix or a hormone-like drug; it mostly acts in the gut by shaping microbiota, inflammation, and the intestinal barrier, with effects that vary by individual gut ecosystems. Its low bioavailability keeps activity local to the intestine, where microbiota may convert it into active compounds. It should be used under medical supervision due to safety concerns and drug interactions, not as a replacement for prescribed meds.
Research shows that maternal consumption of common food additives called emulsifiers can negatively impact the gut microbiota of offspring, leading to increased risks of inflammatory bowel conditions and obesity later in life, highlighting the need for further human studies and regulation of food additives in products like baby formula.
A Brazilian cohort study suggests that high consumption of non-caloric artificial sweeteners may be associated with accelerated cognitive decline over eight years, raising concerns about their long-term safety despite regulatory approval, with potential mechanisms involving neurotoxicity and gut microbiota alterations.
A study found common and distinct patterns in gut bacteria among children with autism, ADHD, and anorexia nervosa, revealing links between gut microbes, appetite hormones, and brain health, though further research is needed due to limitations like small sample size.
Researchers in Spain found a link between the amino acid proline, found in foods like beef and fish, and depression, suggesting that controlling proline levels or its transport to the brain could help prevent or treat depression, with gut bacteria playing a significant role in this process.
The SWEET study is a 1-year randomized controlled trial that found replacing sugar with sweeteners and sweetness enhancers in a healthy, sugar-reduced diet improved weight loss maintenance and altered gut microbiota composition in adults with overweight or obesity, without adverse effects on cardiometabolic health markers.
Researchers discovered that a constipation drug, lubiprostone, can slow kidney function decline in CKD patients by improving gut microbiota and mitochondrial health, showing promise as a new treatment approach.
A Phase II clinical trial led by Tohoku University found that lubiprostone, a drug typically used for constipation, can help prevent the decline of kidney function in CKD patients by improving gut microbiota and mitochondrial function, offering a potential new treatment approach.
Researchers found that gut microbes and immune responses significantly influence autism-like behaviors in mice, with probiotics like L. reuteri IMB015 showing potential as a treatment by restoring neurotransmitter balance and reducing inflammation.
A newly isolated gut bacterium, YB328, enhances the effectiveness of PD-1 blockade immunotherapy by promoting dendritic cell migration and activating T cells, leading to improved cancer treatment responses across various tumor types, as demonstrated in patient samples and mouse models.
A new study suggests that gut bacteria may play a causal role in the development of OCD, identifying specific bacteria linked to increased or decreased risk, which could lead to novel treatment strategies in the future.
New research warns that fecal microbiota transplants (FMT) can cause long-lasting mismatches in gut regions, leading to metabolic and behavioral changes, and proposes omni-microbial transplants to better match microbes with their native gut environments.
A small study found that walnut consumption in adults with obesity improved gut microbiota, reduced gut permeability, and enhanced insulin response, suggesting potential benefits for metabolic health. The study involved controlled dietary interventions with walnuts, walnut oil, and corn oil, showing specific microbial and metabolic changes associated with walnut intake.