Chronoferroptosis: Time-Dependent Iron Stress Weakens Neurons

A Salk Institute study reveals that long-term iron buildup in neurons—rather than brief exposure—gradually erodes antioxidant defenses and elevates lipid peroxidation, triggering chronoferroptosis, a time-dependent stress pathway that leaves neurons vulnerable to stress and points to new preventive therapies to combat neurodegenerative diseases.