Chronoferroptosis: Time-Dependent Iron Stress Weakens Neurons
TL;DR
A Salk Institute study reveals that long-term iron buildup in neurons—rather than brief exposure—gradually erodes antioxidant defenses and elevates lipid peroxidation, triggering chronoferroptosis, a time-dependent stress pathway that leaves neurons vulnerable to stress and points to new preventive therapies to combat neurodegenerative diseases.
Topics:healthscience#chronoferroptosis#ferroptosis#iron-accumulation#lipid-peroxidation#neurodegeneration#science
- Long-Term Iron Accumulation Strips Neurons of Disease Resilience Neuroscience News
- Iron accumulation in the brain may contribute to neurodegeneration Medical Xpress
- Sustained dysregulation of iron and glutathione homeostasis induces chronoferroptosis, a persistent ferroptotic adaptation in neuronal cells | Cell Death Discovery Nature
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