Tag

Ferroptosis

All articles tagged with #ferroptosis

health-and-medicine2 days ago•8 min saved

Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer

Researchers engineered ultrasmall silica nanoparticles (Cornell Prime dots) that target prostate tumors, trigger ferroptosis (iron-driven cell death), and remodel the tumor immune environment to a more active state. In mouse models of aggressive prostate cancer, these particles alone modestly improved survival, but when combined with immune checkpoint therapy they produced complete or near-complete remissions and indefinite survival in 4 of 10 mice, rising to 5 of 10 with an added CSF-1R blockade. The treatment localized to tumors with no observed toxicity in healthy tissues. If safety and efficacy translate to humans, this approach could move toward clinical trials as a multi-pronged cancer therapy that enhances immunotherapy effectiveness.

via ScienceDaily|

#ferroptosis #health-and-medicine #immunotherapy

science15 days ago•9 min saved

Chronoferroptosis: Time-Dependent Iron Stress Weakens Neurons

A Salk Institute study reveals that long-term iron buildup in neurons—rather than brief exposure—gradually erodes antioxidant defenses and elevates lipid peroxidation, triggering chronoferroptosis, a time-dependent stress pathway that leaves neurons vulnerable to stress and points to new preventive therapies to combat neurodegenerative diseases.

via Neuroscience News|

#chronoferroptosis #ferroptosis #iron-accumulation

science20 days ago•6 min saved

Hidden Cancer IDs Spotted by Helper T Cells, Opening New Immunotherapy Avenues

New findings show cancer cells that downregulate MHC I can still be targeted by CD4+ T cells via ferroptosis, expanding the role of helper T cells in cancer immunity and potentially strengthening immunotherapies beyond the traditional CD8+ T cell focus.

via ScienceAlert|

#cancer-immunotherapy #cd4-t-cells #cd8-t-cells

science24 days ago•5 min saved

Ultrasmall silica nanoparticles kill prostate tumors and boost antitumor immunity in mice

In preclinical mouse models, PSMA-targeted ultrasmall core-shell silica nanoparticles (Cornell Prime dots) directly induce ferroptotic death in aggressive prostate tumors and reprogram the tumor microenvironment from nonresponsive to highly active against cancer, while sparing healthy tissue. The particles also sensitize tumors to immunotherapies such as immune checkpoint blockade, with combination treatments yielding complete or near-complete remissions and extended survival in several mice, supporting further clinical investigation for this dual-action anti-cancer approach.

via WCM Newsroom|

#ferroptosis #immunotherapy #prostate-cancer

science26 days ago•5 min saved

Ultrasmall silica nanoparticles kill prostate cancer cells and awaken antitumor immunity

A preclinical study shows PSMA-targeted ultrasmall silica nanoparticles (Cornell Prime dots) directly kill prostate tumor cells by ferroptosis and reprogram the tumor microenvironment to an active antitumor state, enhancing responses to immunotherapies. In mouse models, the particles achieved complete or near-complete remissions, especially when combined with immune checkpoint blockade and CSF-1R blockade, while sparing healthy tissues and showing potential for clinical trial exploration.

via Cornell Chronicle|

#ferroptosis #immunotherapy #nanoparticles

health1 month ago•2 min saved

Olive-Oil Fat May Fuel Pancreatic Cancer, AI and Therapies Offer New Hope

A Yale study finds oleic acid from olive oil can fuel pancreatic ductal adenocarcinoma via ferroptosis, while polyunsaturated fats may slow disease; separately, Mayo Clinic's REDMOD AI can detect pre-diagnostic pancreatic cancer on routine CTs with about 73% sensitivity; CNIO reports a triple-drug combo blocking RAF1, EGFR, and STAT3 that eliminates tumors in experimental models, highlighting advances in precision nutrition, early detection, and combination therapies against this deadly cancer.

via The Daily Wire|

#ai-detection #ferroptosis #health

health-and-medicine1 month ago•6 min saved

Cancer's Escape Trick May Backfire, Unlocking a New Immune Attack

Scientists found that when cancer cells reduce MHC I to dodge killer CD8+ T cells, they become more vulnerable to CD4+ T cells, which trigger ferroptosis. This reveals a surprising cross-talk in the immune system, challenging a long-held immunology principle and suggesting new approaches to cancer immunotherapy and bone marrow transplantation by leveraging CD4+ T cell activity against tumors and allogeneic targets.

via ScienceDaily|

#bone-marrow-transplantation #cancer-immunotherapy #cd4-t-cells

health-and-medicine1 month ago•8 min saved

Different fats push or slow pancreatic cancer in mice

In mice predisposed to pancreatic cancer, oleic acid (the main fat in olive oil) accelerated tumor growth, while omega-3–rich fats from fish oil significantly slowed disease; the effects appear linked to lipid oxidation and ferroptosis, with monounsaturated fats protecting cancer cells and polyunsaturated fats making them more vulnerable. Male mice showed stronger oleic-acid effects. While these findings hint at dietary fat composition influencing cancer risk or progression, human relevance remains unproven and future work may explore fat ratios as prevention or treatment markers or strategies.

via ScienceDaily|

#fats #ferroptosis #health-and-medicine

science1 month ago•7 min saved

MHC I loss unlocks CD4+ T cell attack via ferroptosis in cancer

Lowering MHC I on cancer cells makes them more susceptible to ferroptosis driven by CD4+ T cells, revealing that the MHC I pathway can support CD4+ T cell–mediated immunity and challenging the classic CD4+/CD8+ division; these findings could guide new immunotherapies and bone marrow transplant strategies, especially for tumors that escape CD8+ T cell responses.

via SciTechDaily|

#cancer-immunotherapy #cd4-t-cells #ferroptosis

science1 month ago•5 min saved

Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target

Researchers show cancer cells co-opt vitamin B2 (riboflavin) to power FSP1 and block ferroptosis, a form of cell death. Limiting B2 makes cancer cells more vulnerable, and a B2-mimic called roseoflavin can promote ferroptosis in lab cancer cells, hinting at a targeted therapy that could spare healthy cells. More work is needed to translate this into treatments and to explore ferroptosis' role in other diseases.

via ScienceAlert|

#cancer #ferroptosis #fsp1

science1 month ago•8 min saved

Fat Type Determines Pancreatic Cancer Growth, Study Finds

A Yale-led study in Cancer Discovery shows that the effect of dietary fat on pancreatic cancer depends on fat type, not amount: oleic acid accelerates tumor growth in mice, while omega-3 polyunsaturated fats slow it via ferroptosis; the MUFA/PUFA balance and sex differences also influence outcomes, with human relevance yet to be confirmed.

via SciTechDaily|

#dietary-fats #ferroptosis #oleic-acid

science2 months ago•8 min saved

Cancer-fighting Strategy: Turning Iron-Heavy 'Zombie' Cells Against Their Tumors

Researchers uncovered a vulnerability in senescent “zombie” cells that accumulate in tumors and aging tissues: they rely on GPX4 to shield themselves from iron-driven ferroptosis. Blocking GPX4 with covalent inhibitors exposes these iron-loaded cells to ferroptotic death. In a screen of 10,000 compounds, four senolytics stood out, three targeting GPX4, and testing in three mouse cancer models showed reduced tumor size and improved survival, suggesting potential to combine this approach with chemotherapy or immunotherapy. Ongoing work will identify which cancers and patients are most likely to benefit and how this affects anti-tumor immunity.

via SciTechDaily|

#cancer-therapy #ferroptosis #gpx4

science3 months ago•7 min saved

Vitamin B2 May Help Cancer Cells Avoid Ferroptotic Death

Researchers find that riboflavin (vitamin B2) metabolism supports cancer cells' defenses against ferroptosis, an iron-driven form of cell death, via the FSP1 pathway. Lowering B2 metabolism could make tumors more susceptible to ferroptosis, and roseoflavin—an Anthrobacter-derived compound—triggers ferroptosis in cancer cells at low doses, suggesting a potential therapeutic approach, though specific inhibitors are not yet available.

via SciTechDaily|

#cancer #ferroptosis #fsp1

science4 months ago•33 min saved

Dietary fats steer T cell ferroptosis to modulate immunity

Dietary lipid composition (PUFAs/MUFAs) determines mouse T cell resistance to ferroptosis, shaping T cell homeostasis and immune responses via lipid remodeling; these diet‑induced ferroptosis effects (DEFs) are microbiota‑independent and correlate with human plasma lipid profiles, with PUFA‑containing phospholipids driven by ACSL4 underpinning TFH cell development and broader T cell–mediated immunity, including anti‑tumor responses and CAR‑T therapy. The findings suggest targeting lipid metabolism could enhance vaccines and immunotherapies.

via Nature|

#acsl4 #ferroptosis #immunity

science6 months ago•3 min saved

Uncovering the Cause of Brain Cell Death in Rare Genetic Mutation

Researchers have uncovered how a rare genetic mutation in the GPX4 gene causes neurodegeneration through ferroptosis, a form of cell death linked to oxidative damage, providing new insights into diseases like Alzheimer's and childhood dementia.

via ScienceAlert|

#brain-cells #dementia #ferroptosis