tldrdailynews.com logo
Tag

Ferroptosis

All articles tagged with #ferroptosis

Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target
science1 day ago

Vitamin B2 Gives Cancer Cells a Ferroptosis Shield, Pointing to a New Treatment Target

Researchers show cancer cells co-opt vitamin B2 (riboflavin) to power FSP1 and block ferroptosis, a form of cell death. Limiting B2 makes cancer cells more vulnerable, and a B2-mimic called roseoflavin can promote ferroptosis in lab cancer cells, hinting at a targeted therapy that could spare healthy cells. More work is needed to translate this into treatments and to explore ferroptosis' role in other diseases.

via ScienceAlert|
#cancer#ferroptosis#fsp1
Cancer-fighting Strategy: Turning Iron-Heavy 'Zombie' Cells Against Their Tumors
science24 days ago

Cancer-fighting Strategy: Turning Iron-Heavy 'Zombie' Cells Against Their Tumors

Researchers uncovered a vulnerability in senescent “zombie” cells that accumulate in tumors and aging tissues: they rely on GPX4 to shield themselves from iron-driven ferroptosis. Blocking GPX4 with covalent inhibitors exposes these iron-loaded cells to ferroptotic death. In a screen of 10,000 compounds, four senolytics stood out, three targeting GPX4, and testing in three mouse cancer models showed reduced tumor size and improved survival, suggesting potential to combine this approach with chemotherapy or immunotherapy. Ongoing work will identify which cancers and patients are most likely to benefit and how this affects anti-tumor immunity.

via SciTechDaily|
#cancer-therapy#ferroptosis#gpx4
Vitamin B2 May Help Cancer Cells Avoid Ferroptotic Death
science2 months ago

Vitamin B2 May Help Cancer Cells Avoid Ferroptotic Death

Researchers find that riboflavin (vitamin B2) metabolism supports cancer cells' defenses against ferroptosis, an iron-driven form of cell death, via the FSP1 pathway. Lowering B2 metabolism could make tumors more susceptible to ferroptosis, and roseoflavin—an Anthrobacter-derived compound—triggers ferroptosis in cancer cells at low doses, suggesting a potential therapeutic approach, though specific inhibitors are not yet available.

via SciTechDaily|
#cancer#ferroptosis#fsp1
Dietary fats steer T cell ferroptosis to modulate immunity
science2 months ago

Dietary fats steer T cell ferroptosis to modulate immunity

Dietary lipid composition (PUFAs/MUFAs) determines mouse T cell resistance to ferroptosis, shaping T cell homeostasis and immune responses via lipid remodeling; these diet‑induced ferroptosis effects (DEFs) are microbiota‑independent and correlate with human plasma lipid profiles, with PUFA‑containing phospholipids driven by ACSL4 underpinning TFH cell development and broader T cell–mediated immunity, including anti‑tumor responses and CAR‑T therapy. The findings suggest targeting lipid metabolism could enhance vaccines and immunotherapies.

via Nature|
#acsl4#ferroptosis#immunity
Lymph Node Environment Influences FSP1 Targeting and Ferroptosis in Melanoma and Lung Cancer
cancer-research6 months ago

Lymph Node Environment Influences FSP1 Targeting and Ferroptosis in Melanoma and Lung Cancer

The study reveals that the lymph node microenvironment promotes resistance to ferroptosis in metastasizing melanoma by downregulating GSH synthesis and upregulating FSP1, which localizes to lysosomes and provides a GPX4-independent protective mechanism. Oxygen levels and epigenetic regulation influence GPX4 stability and ferroptosis sensitivity, suggesting potential therapeutic strategies targeting FSP1 and GSH synthesis in LN metastases.

via Nature|
#cancer-research#ferroptosis#fsp1
"Lipid Control of Ferroptosis: Unveiling Cell Death Secrets"
science2 years ago

"Lipid Control of Ferroptosis: Unveiling Cell Death Secrets"

Researchers at Columbia University have identified a rare lipid, diPUFA phospholipid, as a crucial factor in promoting ferroptosis, a unique form of cell death. This discovery has significant implications for treating neurodegenerative diseases and cancer, as it opens new avenues for either preventing or inducing cell death. The interdisciplinary research involved the Department of Biological Sciences, Department of Chemistry, and the Columbia University Irving Medical Center, and the findings deepen our understanding of ferroptosis and its potential for controlling cell death.

via Neuroscience News|
#cancer#cell-death#ferroptosis
"Cholesterol Precursor 7-Dehydrocholesterol Suppresses Ferroptosis Sensitivity in Cells"
scientific-research2 years ago

"Cholesterol Precursor 7-Dehydrocholesterol Suppresses Ferroptosis Sensitivity in Cells"

A study has found that 7-dehydrocholesterol, a precursor to cholesterol, plays a crucial role in determining the sensitivity of cells to ferroptosis, a form of cell death. The research, which utilized CRISPR screening and lipidomic analysis, provides insights into the mechanisms underlying ferroptosis and its potential implications for various diseases. The data from the study are available online, contributing to the accessibility and reproducibility of the findings.

via Nature.com|
#cholesterol#crispr#data-availability
"Cholesterol Precursor 7-Dehydrocholesterol Suppresses Ferroptosis in Cells"
scientific-research2 years ago

"Cholesterol Precursor 7-Dehydrocholesterol Suppresses Ferroptosis in Cells"

A study has identified 7-dehydrocholesterol as a natural inhibitor of ferroptosis, a form of cell death driven by lipid peroxidation. The research sheds light on the role of 7-dehydrocholesterol-derived oxysterols in regulating ferroptosis sensitivity and provides insights into the mechanisms of this type of cell death. The data and materials supporting the findings are available in the main text, figures, and extended data figures, as well as in a repository for (epi)lipidomics experiments.

via Nature.com|
#7-dehydrocholesterol#cell-death#ferroptosis