Global Mega-Analysis Finds Common Brain Signature Across Psychedelics

An international mega-analysis pooling over 500 brain-imaging sessions from 267 participants across five countries shows that psychedelics (psilocybin, LSD, mescaline, DMT, ayahuasca) produce a shared brain fingerprint: weakening within-network connectivity and increasing cross-network communication, leading to a more flexible, less modular brain state. This two-part pattern explains common therapeutic and perceptual effects across diverse drugs and provides a benchmark to guide future research and regulatory considerations.