Tag

Meta Analysis

All articles tagged with #meta analysis

science23 hours ago•15 min saved

Fish-Oil Fatty Acids Linked to Broad Reductions in Aggression, Large Meta-Analysis Shows

A meta-analysis of 29 randomized trials (3,918 participants, 1996–2024) finds omega-3 supplementation modestly reduces aggression—up to 28% in the strongest lab-based estimate—across age groups, sexes, diagnoses, durations, and doses, with both reactive and proactive aggression affected. Proposed mechanisms include anti-inflammatory effects, changes to neuronal membrane composition, and maintained prefrontal cortex function. While not a magic bullet, the intervention is safe and cheap, with potential implications for parenting, correctional facilities, and public health, though adoption may be slowed by cultural biases against nutritional explanations of violence.

via Space Daily|

#aggression #meta-analysis #neuroscience

health1 day ago•5 min saved

Omega-3 Supplements Cut Aggression by Up to 28%, Meta-Analysis Finds

A 2024 meta-analysis of 29 randomized controlled trials (3,918 participants) found that omega-3 supplementation via fish oil can moderately reduce aggression in the short term (up to 28%), across ages and different settings, suggesting omega-3 could be a helpful adjunct to other interventions, though it is not a cure and longer-term research is needed.

via ScienceAlert|

#aggression #fish-oil #health

health4 days ago•8 min saved

Cheap Digoxin May Cut Hospitalizations in Heart Failure Patients

UMCG-led studies suggest adding a low-dose digoxin to standard heart failure therapy reduces cardiovascular death risk and HF-related hospitalizations. A broader meta-analysis found a significant ~25% reduction in HF admissions, supporting digoxin’s safety and cost-effectiveness at under ten cents per day. If confirmed, these findings could influence guidelines and broaden access to this inexpensive, centuries-old treatment.

via SciTechDaily|

#digoxin #health #heart-failure

science10 days ago•6 min saved

Brain choline deficit linked to anxiety hints at dietary approaches

A UC Davis Health meta-analysis of 25 studies found people with anxiety disorders have about 8% lower brain choline levels, especially in the prefrontal cortex, suggesting nutrition could influence brain chemistry and anxiety, but more research is needed before dietary changes or supplements are recommended.

via ScienceDaily|

#anxiety-disorders #brain-chemistry #choline

health11 days ago•3 min saved

Pregnancy antidepressants not tied to autism or ADHD risk, meta-analysis suggests

A large meta-analysis of over half a million pregnancies found no significant link between maternal antidepressant use during pregnancy and autism or ADHD in children after adjusting for maternal mental health and other factors; any initial signals disappeared when confounders were controlled. The findings support continuing antidepressant treatment for moderate-to-severe depression during pregnancy, though decisions should be individualized with a clinician and study limitations include missing socioeconomic and lifestyle data.

via The Guardian|

#adhd #antidepressants #autism

science1 month ago•6 min saved

High Chili Pepper Intake Linked to Increased GI Cancer Risk, Especially Esophagus

A meta-analysis of 14 observational studies involving over 11,000 participants found that high chili pepper consumption was associated with about a 64% higher risk of gastrointestinal cancers overall, with the strongest link for esophageal cancer (nearly a threefold increase). Regional differences were noted, and no causal relationship can be established due to the observational nature of the data; more research is needed to determine safe intake levels and underlying mechanisms.

via SciTechDaily|

#capsaicin #chili-peppers #esophageal-cancer

science1 month ago•6 min saved

Global Mega-Analysis Finds Common Brain Signature Across Psychedelics

An international mega-analysis pooling over 500 brain-imaging sessions from 267 participants across five countries shows that psychedelics (psilocybin, LSD, mescaline, DMT, ayahuasca) produce a shared brain fingerprint: weakening within-network connectivity and increasing cross-network communication, leading to a more flexible, less modular brain state. This two-part pattern explains common therapeutic and perceptual effects across diverse drugs and provides a benchmark to guide future research and regulatory considerations.

via Neuroscience News|

#brain-imaging #mental-health #meta-analysis

health1 month ago•5 min saved

Modest but Real Gains from Collagen Supplements, Large Review Finds

A large synthesis of 113 clinical trials and 16 systematic reviews (nearly 8,000 participants) finds collagen supplements offer modest but real benefits: improvements in muscle health and osteoarthritis pain, plus better skin hydration and elasticity with consistent, longer-term use. However, results vary by product type, dose, and study quality, and many trials are short or poorly designed, leaving long-term effects and who benefits most still unclear; more standardized research is needed.

via ScienceAlert|

#collagen #health #joints

health1 month ago•5 min saved

High-Intensity Yoga Emerges as Top Sleep Booster in New Review

A global meta-analysis of 30 randomized trials finds that high-intensity yoga, practiced under 30 minutes twice weekly for 8–10 weeks, most effectively improves sleep quality in people with sleep disturbances, outperforming walking, resistance training, and other exercises, though results vary and more high-quality research is needed.

via ScienceAlert|

#exercise #health #meta-analysis

health2 months ago•10 min saved

Collagen Supplements Offer Modest Skin and Joint Benefits, but Evidence Remains Inconsistent

A large review of 113 clinical trials (up to March 2025, about 8,000 participants) finds collagen supplements are associated with modest improvements in muscle health, reduced osteoarthritis pain, and improved skin hydration and elasticity with longer use, but results vary by product type and study quality is often low, meaning long-term effects and which people benefit most remain uncertain.

via The Conversation|

#collagen #health #joints

health2 months ago•16 min saved

Psychedelic Antidepressants Aren't Proving More Effective Than Open-Label Traditional Antidepressants, Meta-Analysis Finds

A new meta-analysis of 24 trials finds psychedelics can help treat depression but are not more effective than open-label traditional antidepressants, suggesting biases and placebo effects may have inflated earlier hype.

via Gizmodo|

#antidepressants #depression #health

health2 months ago•14 min saved

Isometric workouts: a 14-minute, thrice-weekly route to lower blood pressure

A recent meta-analysis of isometric exercises (handgrip, wall squat, leg extension) suggests that doing four 2‑minute bouts, three days a week for a total of 14 minutes per session can lower blood pressure and improve heart function—often more effectively than cardio or resistance training. The routine is accessible at home without equipment and may help those with joint or mobility issues, though long‑term effects and interactions with blood pressure medications need more study; ongoing large trials aim to refine the optimal protocols.

via BBC|

#blood-pressure #cardiovascular-health #health

health2 months ago•7 min saved

Most Sleep Aids Safe for Obstructive Sleep Apnea, Temazepam Notable Risk

A Japanese-led network meta-analysis of 32 randomized trials across 12 hypnotics in adults with COMISA found that most sleep medications do not significantly worsen respiratory outcomes or oxygen levels compared with placebo; temazepam stood out as potentially lowering nocturnal oxygen saturation. The study supports symptom-driven drug choices and notes CPAP remains the gold standard, with meds offering a viable plan B for those who struggle with CPAP tolerance.

via Neuroscience News|

#comisa #health #hypnotics

autism2 months ago•24 min saved

Autism study finds females show larger cognitive shifts than males

A large meta-analysis of 34 studies (over 1.2 million participants) finds autistic females exhibit larger departures from the typical female cognitive profile than autistic males do from the typical male profile, supporting a female protective effect and a stronger application of the Extreme Male Brain theory to females; empathy shifts drive the signal more than systemizing, with a notable cognitive trade-off in autism. Limitations include reliance on self-reports and sample clustering, underscoring the need for further research to improve identification of autistic females.

via PsyPost|

#autism #empathizing #femaleprotectiveeffect

science3 months ago•6 min saved

Fasting Generally Doesn’t Impair Adults’ Thinking, Large Review Finds

A sweeping meta-analysis of 63 studies (3,484 participants) finds no meaningful difference in cognitive performance between fasted and fed healthy adults. Age matters (children fare worse when fasting); longer fasts may lessen performance gaps as ketones supply energy; testing later in the day and the presence of food cues can influence results; and the type of cognitive task matters. Overall, fasting appears compatible with maintained mental sharpness in adults, with caveats for kids and certain contexts, while metabolic benefits like autophagy and improved insulin sensitivity are noted but vary by individual.

via ScienceAlert|

#autophagy #cognitive-performance #fasting