GPR133 Receptor Emerges as a New Target to Strengthen Bones

Leipzig University researchers have identified GPR133 (ADGRD1) as a mechanosensitive receptor that promotes bone formation and limits bone resorption, strengthening bones. The receptor can be activated by AP503, which improved bone strength in both healthy and osteoporosis-model mice, offering a potential new drug target for osteoporosis and possibly age-related bone and muscle decline. Findings are preclinical, and further studies are needed before human treatments.