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Osteoporosis

All articles tagged with #osteoporosis

Calcium and vitamin D supplements offer little fracture protection, review finds
health3 days ago

Calcium and vitamin D supplements offer little fracture protection, review finds

A BMJ meta-analysis of 69 randomized trials involving about 154,000 mostly older adults found that calcium, vitamin D, or their combination provide little to no reduction in fractures or falls, with any absolute benefit not clinically meaningful. The findings do not support routine supplementation for the general population, though results may differ for people with osteoporosis or high fracture risk who should follow established treatments and guidelines.

via Pulse Today|
#bone-health#calcium#fractures
Tea Tied to Slightly Stronger Hips, Heavy Coffee May Lower Bone Density
health5 days ago

Tea Tied to Slightly Stronger Hips, Heavy Coffee May Lower Bone Density

A decade-long study of nearly 10,000 older women found that regular tea drinkers had modestly higher hip bone density than non-tea drinkers, while heavy coffee intake (>5 cups/day) was linked to lower bone density. Moderate coffee (2–3 cups/day) showed no harm, but very high consumption combined with higher alcohol intake amplified negative effects. The researchers note small individual changes can translate to fewer fractures at population level, but emphasize that calcium, vitamin D, exercise, and not smoking remain the most important factors for osteoporosis. Limitations include a mostly White US cohort and self-reported beverage intake.

via SciTechDaily|
#bone-density#coffee#health
Spaceflight bone loss reshapes osteoporosis treatment on Earth
science6 days ago

Spaceflight bone loss reshapes osteoporosis treatment on Earth

Astronauts on the ISS lose 1-2% of bone mineral density per month due to microgravity, so a six‑month mission can erase roughly a year’s worth of bone mass for a postmenopausal person. NASA’s countermeasures—ARED-based resistance exercise, cardio, and, in some cases, alendronate—partially slow the loss but do not prevent it, and recovery after return remains incomplete, effectively aging skeletal health by about a decade for longer missions. These findings are driving terrestrial osteoporosis research and potential treatments, though transfer to Earth is not direct and requires clinical adaptation.

via Space Daily|
#bone-density#countermeasures#iss
Tea May Help Bones of Older Women, Coffee Could Hamper Them
health20 days ago

Tea May Help Bones of Older Women, Coffee Could Hamper Them

A study of about 9,700 US women over 65 found regular tea drinkers had modestly higher hip bone mineral density, possibly due to tea catechins, while higher coffee intake (>5 cups/day) correlated with lower bone density, especially among lifetime alcohol consumers; results suggest tea may support bone health but do not recommend increasing coffee, and calcium/vitamin D remain key to bone health.

via ScienceAlert|
#bone-mineral-density#coffee#elderly-women
Bone-strong aging: science-backed tips for healthier bones
wellbeing25 days ago

Bone-strong aging: science-backed tips for healthier bones

Experts say bone strength matters as you age and can be supported with regular strength training to boost density, a Mediterranean-style diet rich in protein, calcium, and vitamin D, and avoiding smoking and heavy alcohol use. While some supplements show promise, long-term benefits aren’t proven, so focus on consistent exercise, nutrition, and lifestyle choices to prevent osteoporosis and fractures.

via The Washington Post|
#exercise#healthy-eating#osteoporosis
Bone-Strength Switch Found: GPR133 May Redefine Osteoporosis Therapy
science1 month ago

Bone-Strength Switch Found: GPR133 May Redefine Osteoporosis Therapy

Scientists identified GPR133 as a receptor that senses mechanical strain and coordinates osteoblasts and osteoclasts, acting as a switch to boost bone formation while reducing bone degradation. In mice, activating GPR133 with the compound AP503 increased bone strength in both healthy and osteoporosis models, suggesting a balanced, potentially safer new approach to osteoporosis treatment, though human trials are needed.

via Indian Defence Review|
#bone-remodeling#gpr133#osteoblast
GPR133 Receptor Emerges as a New Target to Strengthen Bones
science1 month ago

GPR133 Receptor Emerges as a New Target to Strengthen Bones

Leipzig University researchers have identified GPR133 (ADGRD1) as a mechanosensitive receptor that promotes bone formation and limits bone resorption, strengthening bones. The receptor can be activated by AP503, which improved bone strength in both healthy and osteoporosis-model mice, offering a potential new drug target for osteoporosis and possibly age-related bone and muscle decline. Findings are preclinical, and further studies are needed before human treatments.

via SciTechDaily|
#ap503#bone-density#gpr133
Bone Density Gains Take Time: 1 to 3 Years to See Real Change
health1 month ago

Bone Density Gains Take Time: 1 to 3 Years to See Real Change

Bone density peaks before age 30 and begins to decline after 40, so prevention matters early, but you can slow loss at any age with weight-bearing exercise and good nutrition. Experts recommend about 150 minutes of moderate activity weekly plus two days of strength training, and calcium and vitamin D from foods or fortified sources spread across meals. Changes in density typically show up on a DEXA scan after 1–3 years; menopause accelerates loss (roughly 3% per year) before it slows to about 1% afterward, and avoiding smoking, heavy alcohol, and certain medications helps preserve density.

via Women's Health|
#bone-density#calcium#health
Five to Six Prunes a Day May Protect Hip Bones in Postmenopausal Women
health1 month ago

Five to Six Prunes a Day May Protect Hip Bones in Postmenopausal Women

A year-long study of 235 postmenopausal women found that consuming 50g (about five to six) prunes daily preserved hip bone density and improved bone-structure measures, with better adherence at the 50g level. While results suggest prunes may help reduce osteoporosis risk and fracture chances, further research is needed to confirm and expand on these findings.

via HuffPost UK|
#bone-density#health#hip-fracture-risk
Activating GPR133 May Rebuild Bone in Osteoporosis
science2 months ago

Activating GPR133 May Rebuild Bone in Osteoporosis

New research shows that activating the GPR133 receptor with the compound AP503 boosts osteoblast-driven bone formation, dramatically increasing bone density and strength in osteoporotic mice and even stronger when combined with exercise; the approach could shift osteoporosis treatment from slowing bone loss to rebuilding bone, but it remains early-stage animal research with no human trials yet.

via Indian Defence Review|
#ap503#bone-density#gpr133
GPR133 Activation Boosts Bone Strength in Mice, Hinting at Osteoporosis Therapies
science2 months ago

GPR133 Activation Boosts Bone Strength in Mice, Hinting at Osteoporosis Therapies

A 2025 study from Leipzig and Shandong identifies the GPR133 (ADGRD1) receptor as crucial for bone density. Activating it with the chemical AP503 increases osteoblast activity and bone strength in mice, suggesting a potential therapy for osteoporosis that could work with exercise. While promising, these results are in animal models and require human testing; related 2024 work on a blood‑based regenerative implant and bone‑density hormones may inform future treatments.

via ScienceAlert|
#ap503#bone-density#gpr133
GLP-1 Medications Show Small Increase in Bone-Health Risks, Study Finds
health2 months ago

GLP-1 Medications Show Small Increase in Bone-Health Risks, Study Finds

A five-year study of 73,483 people starting GLP-1 medications (e.g., semaglutide, liraglutide, dulaglutide, exenatide) and 73,483 matched controls found small but statistically significant increases in osteoporosis (0.9%), gout (0.8%), and osteomalacia (0.1%) among GLP-1 users. The study does not prove causation and factors like diet and exercise were not analyzed. The findings could inform bone-health surveillance and more personalized prescribing, though GLP-1 therapies also offer metabolic benefits and long-term effects require further study.

via ScienceAlert|
#glp-1#gout#health