Gut CNMa Rewires Cravings: Protein Over Sweets
TL;DR Summary
A new study reveals a two-track gut-brain signaling system: gut cells release CNMa in response to protein deficiency, triggering a fast neural alert to the brain and a slower hormonal signal that sustains a protein-seeking appetite while suppressing sugar cravings by dampening DH44 sugar neurons; gut microbes modulate this pathway and the mechanism is conserved in mice, independent of FGF21, suggesting novel targets for obesity and eating disorders.
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