Massive brain-imaging study finds ethnic differences in Alzheimer's amyloid biology

A large-scale analysis of brain imaging from 17,017 older adults across five cohorts used the Centiloid standard to compare amyloid burden. The study found Hispanic participants generally have lower amyloid levels and a weaker link between APOE ε4 and amyloid than non-Hispanic whites with similar risk, implying Alzheimer’s biology may differ across populations and highlighting the need for diverse data to guide treatments.