Sex-Specific Gene Activity Mapped Across Brain Cells
TL;DR Summary
A single-cell analysis of over a million brain cells from six cortical regions in 30 people found subtle but widespread sex differences in gene activity, with more than 100 genes showing consistent sex-related expression patterns. Sex accounts for less than 1% of overall gene-expression variation, but these molecular signatures could help explain why risks for conditions like schizophrenia and Alzheimer's differ by sex and how hormonal environments might modulate brain biology across life.
- Revealed: how male and female brain cells differ in gene activity Nature
- Why Men and Women Process Mental Risk Differently Neuroscience News
- Study Offers a “Treasure Trove” of Clues to Sex Differences in the Brain the-scientist.com
- Sex-specific gene expression in the brain linked to disease risk 동아사이언스
- High-resolution study maps molecular differences across six human cortical regions News-Medical
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