All articles tagged with #gene expression
Scientists identified DHX29 as a key regulator that senses non-optimal codons during translation, binding to ribosomes decoding these codons and recruiting the GIGYF2•4EHP complex to suppress certain mRNAs. This reveals a second regulatory layer in the genetic code that links synonymous codon choice to gene expression and may influence development and disease.
A new study finds autism symptom severity, not diagnostic labels, maps to shared brain-network connectivity and gene-expression patterns linked to autism and ADHD, suggesting a common biology across neurodevelopmental conditions.
MIT/Harvard researchers reprogrammed cellular vaults to bind and preserve mRNA, turning them into a living time capsule that records a cell’s gene-expression changes during stress and treatment, enabling retrospective insights without destroying the cell.
A study identifies OTULIN as a high-level regulator in neurons that controls gene expression and RNA metabolism, shaping tau biology in brain aging and Alzheimer's disease. Partial inhibition of OTULIN reduced pathogenic tau, while CRISPR deletion nearly abolished tau by silencing MAPT mRNA, but also caused widespread transcriptome changes. The work suggests therapies could recalibrate neuronal regulatory networks to counter aging and neurodegeneration, though complete loss of OTULIN would be harmful and requires precise tuning.
A large study of African American brains has identified the ADAMTS2 gene as significantly linked to Alzheimer's disease, with higher activity levels observed in affected individuals, suggesting a shared biological pathway across populations and potential for targeted therapies.
Recent research suggests that drinking orange juice can benefit heart health by lowering blood pressure and inflammation, and improving fat metabolism, with effects varying based on body type. The study highlights molecular mechanisms behind these benefits, though moderation is advised due to sugar content, and whole fruits are recommended over juice for additional fiber and nutrients.
A large-scale study of brain tissue from African Americans with Alzheimer's disease identified significant genetic signals, notably an increased expression of the ADAMTS2 gene, which is also linked to Alzheimer's in White populations, suggesting shared biological mechanisms across races.
A study in mice reveals that fasting enhances breast cancer treatment by affecting hormone signaling pathways and gene expression, potentially improving therapy outcomes and delaying resistance.
A study finds that autism symptom severity in children with autism and ADHD is linked to shared patterns of brain connectivity and gene expression, regardless of diagnosis, suggesting a common biological basis and supporting dimensional models of neurodevelopmental conditions.
A study finds that autism symptom severity, regardless of diagnosis, correlates with shared brain connectivity patterns and gene expression profiles in children with autism or ADHD, supporting a dimensional and biological approach to understanding neurodevelopmental conditions.
Scientists have identified two existing cancer drugs, letrozole and irinotecan, that can reverse brain damage associated with Alzheimer's in mice, showing promise for future clinical trials and potential treatment options for humans.
The study investigates how lymphoid gene expression supports neuroprotective functions of microglia in the human brain, particularly in the context of Alzheimer's disease, using post-mortem samples, induced pluripotent stem cells, and mouse models to explore microglial roles and gene regulation.
An AI model called DrugReflector, trained on gene expression data, significantly accelerates drug discovery by more effectively identifying promising compounds, doubling success rates when iteratively refined, and offering a powerful new tool for developing therapies.
Researchers developed spVelo, a new method using neural networks to improve the measurement of gene expression changes and cell fate decisions by incorporating spatial and batch information, enabling more accurate and comprehensive analysis of cellular development and differentiation.
Scientists have discovered that disordered gene-regulating proteins rely on a structured partner, beta-catenin, to function properly, challenging previous ideas about their chaotic nature and revealing a hidden organization that could impact understanding of gene control and disease.