Vitamin K Orchestrates Bone Remodeling via GAS6 Signaling

A study reveals a vitamin K–dependent signaling pathway in osteoblasts that regulates osteoclast maturation and bone resorption via GAS6-TAM signaling; deleting γ-glutamyl carboxylase in osteoblasts increases bone mass by reducing resorption, while GAS6 stimulates osteoclast formation; elevated GAS6 lowers bone density in vivo, highlighting GAS6/TAM signaling as a potential osteoporosis target.