Tag

Osteoblast

All articles tagged with #osteoblast

science3 hours ago•8 min saved

Vitamin K Orchestrates Bone Remodeling via GAS6 Signaling

A study reveals a vitamin K–dependent signaling pathway in osteoblasts that regulates osteoclast maturation and bone resorption via GAS6-TAM signaling; deleting γ-glutamyl carboxylase in osteoblasts increases bone mass by reducing resorption, while GAS6 stimulates osteoclast formation; elevated GAS6 lowers bone density in vivo, highlighting GAS6/TAM signaling as a potential osteoporosis target.

via SciTechDaily|

#bone-remodeling #gas6 #osteoblast

science1 month ago•9 min saved

Bone-Strength Switch Found: GPR133 May Redefine Osteoporosis Therapy

Scientists identified GPR133 as a receptor that senses mechanical strain and coordinates osteoblasts and osteoclasts, acting as a switch to boost bone formation while reducing bone degradation. In mice, activating GPR133 with the compound AP503 increased bone strength in both healthy and osteoporosis models, suggesting a balanced, potentially safer new approach to osteoporosis treatment, though human trials are needed.

via Indian Defence Review|

#bone-remodeling #gpr133 #osteoblast