Protein Mitch Reprograms Fat Metabolism, Hinting at Next-Gen Obesity Therapies
TL;DR
Researchers at the Weizmann Institute identified MTCH2, nicknamed Mitch, as a key regulator of fat fate and energy use. Blocking Mitch in muscle and precursor fat cells drives increased fat oxidation and suppresses new fat-cell formation, and mice lacking Mitch stayed lean with more muscle and improved heart function. The findings suggest a potential obesity treatment that boosts fat burning while preserving muscle, though human therapies are not yet available and further research is needed.
- 'Mitch' protein that could change the future of weight loss and fat burning New York Post
- Study identifies key mechanism regulating how cells use fat to generate energy Phys.org
- Scientists discover a protein switch that burns fat and blocks new fat cells ScienceDaily
- Turning Off a Protein Called ‘Mitch’ Made Mice Virtually Immune to Obesity. Scientists Just Tested It In Human Cells ZME Science
- Protein discovery could help burn fat without losing muscle NewsNation
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