Tag

Mtch2

All articles tagged with #mtch2

health1 day ago•5 min saved

Protein Mitch Reprograms Fat Metabolism, Hinting at Next-Gen Obesity Therapies

Researchers at the Weizmann Institute identified MTCH2, nicknamed Mitch, as a key regulator of fat fate and energy use. Blocking Mitch in muscle and precursor fat cells drives increased fat oxidation and suppresses new fat-cell formation, and mice lacking Mitch stayed lean with more muscle and improved heart function. The findings suggest a potential obesity treatment that boosts fat burning while preserving muscle, though human therapies are not yet available and further research is needed.

via New York Post|

#fat-burning #health #metabolism

science5 days ago•5 min saved

Mitch protein switch makes human cells burn fats for energy, opening obesity research avenue

Weizmann Institute researchers showed that deleting MTCH2 (Mitch) in human cells triggers a hypermetabolic state: mitochondria burn more fuel, especially fats, while fat storage and fat-cell formation are reduced, shedding light on MTCH2 as a regulator of cellular energy and obesity—though translating this into safe human therapies will require extensive follow-up.

via ScienceAlert|

#adipogenesis #metabolism #mitch

science8 days ago•5 min saved

MTCH2 protein switch could boost fat burn while hindering new fat cells

Researchers identify MTCH2 ('Mitch') as a regulator of mitochondrial fusion; deleting Mitch in human cells fragments mitochondria and increases energy demand, boosting fat and carbohydrate breakdown and reducing new fat-cell formation. In mice, Mitch suppression in muscle improves endurance and protects against obesity. The findings point to Mitch as a potential target to enhance fat burning while limiting fat storage, though the work is early-stage and preclinical.

via ScienceDaily|

#adipogenesis #fat-metabolism #mitochondria