Revolutionary technique for studying genome architecture and interactions.

Scientists at the Berlin Institute of Medical Systems Biology of the Max Delbrück Center have developed a technique called Genome Architecture Mapping (GAM) to study the genome's spatial architecture. GAM reveals information about the genome's spatial architecture that is invisible to scientists using solely Hi-C, a workhorse tool developed in 2009 to study DNA interactions. Understanding DNA organization can reveal the basis of health and disease. Changes to the three-dimensional configuration can disrupt this process and cause disease.