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Ahr

All articles tagged with #ahr

science1 month ago•6 min saved

Blocking a cellular brake unlocks nerve regeneration after injury

Researchers identified the aryl hydrocarbon receptor (AHR) as a molecular brake that restrains injured neurons from regrowing axons. Blocking AHR in mice—genetically or pharmacologically—enhanced axon regeneration and improved movement and sensation after peripheral nerve or spinal cord injuries. The effect shifts neurons from a stress-management mode to growth, aided by HIF-1α, and suggests potential therapeutic avenues, though work remains to determine timing, dosing, and safety before human use.

via Science Daily|

#ahr #axon-regeneration #nerve-injury

science6 months ago•7 min saved

Blocking AHR May Unleash Nerve Regrowth After Injury

Mount Sinai researchers identify the aryl hydrocarbon receptor (AHR) as a molecular brake that shifts injured neurons toward managing stress rather than regrowing connections. Inhibiting AHR in mouse models enhances axon regeneration and improves movement and sensation, by allowing a growth-focused protein production program and involving the HIF-1α pathway. The study suggests AHR inhibitors or gene therapy could potentially boost nerve repair after injuries to the peripheral nerves or spinal cord, but further work is needed before clinical use.

via SciTechDaily|

#ahr #axongrowth #hif-1a